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Clec5a - Model 13791 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 13791
    C57BL/6-Clec5atm1.2Mrl
  • The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic's C57BL/6N Tac ES cell line.
  • Clec5a exons 1 to 6 have been replaced by the FRT site flanked neomycin resistance gene cassette.
  • The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
  • The constitutive KO line has been derived using C57BL/6NTac animals.
  • Deletion of exons 1 to 6 should result in loss of function of the Clec5a gene.
  • The remaining recombination sites are located in non-conserved regions of the genome.
  • Datamining and Design performed in 2004.

Gene Family:

Lectin

Genetic Background:

C57BL/6

Gene Symbol:

Clec5a (Mdl1)

Gene Accession Number:

NM_021364

Allele Type:

KO

Source:

DNAX 3

Availability:

Cryopreserved at Taconic

Species:

Mouse

Official Gene Name:

C-type lectin domain family 5, member a

For Profit Pricing:

Price per Line ($)
$30,000

Nonprofit Pricing:

Price per Line ($)
$5,500

For Profit Pricing:

Price per Line (€)
€27,300

Nonprofit Pricing:

Price per Line (€)
€5,005
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice heterozygous for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 heterozygous mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.