Bud31 - Model 6501 - KO

• The targeting vector has been generated using 129SvEv DNA and transfected into 129SvEv ES cell line.
• Bud31 (Edg2) coding exon was disrupted by the neomycin resistance cassette, which is flanked by loxP sites.
• Chimeric mice were produced and germ line transmission achieved.
• The neomycin resistance gene has not been deleted in the constitutive KO mice.
• Disruption of the coding sequence should result in loss of function of the Bud31 (Edg2) gene by deleting functional domains of the protein.
• Bud31 (Edg2) constitutive KO mice are in a mixed C57BL/6-129SvEv genetic background.

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

• GEM Collection Commercial Terms of Sale
• GEM Collection Academic Terms of Sale

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

• A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
• Validated genotyping protocols
• Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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