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Bcl2l11 - Model 11035 - cTTG

Targeted Transgenic

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 11035
    C57BL/6-tm1.1 (CAG-Bcl2l11)Mrl
  • The targeting vector has been transfected into the TaconicArtemis C57BL/6NTac ES cell line.
  • The following elements have been inserted into the ROSA26 locus:

    • A CAG promoter cassette (containing a cytomegalovirus early enhancer element, a chicken beta-actin promoter and an adenovirus intron).
    • Lox-P flanked hGHpA cassette to stop the transcription of the Bcl2l11 cDNA.
    • The Bcl2l11 open reading frame (based on NCBI transcript NM_009754).
    • A synthetic polyadenylation signal.
    • A Neomycin resistance (NeoR) cassette containing a polyadenylation signal and lacking a translation initiation codon.

  • The conditional TTG line has been generated by crossing chimeras to C57BL/6NTac animals.
  • The constitutive TTG allele can be generated by Cre-mediated recombination by crossing line 11035 to a Cre-Deleter. Deletion of hGHpA cassette should result in transcription of the cDNA
  • The Bcl2l11 protein is expressed under the control of the CAG promoter.
  • The presence of the NeoR cassette terminates the transcription from the ROSA26 promoter.
  • Datamining and Design performed in 2007.

Gene Family:

Enzyme activator

Genetic Background:

C57BL/6

Gene Symbol:

Bcl2l11

Gene Accession Number:

NM_207681

Allele Type:

cTTG

Source:

TaconicArtemis

Availability:

Cryopreserved at Taconic

Species:

Mouse

Official Gene Name:

BCL2-like 11 (apoptosis facilitator)

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

For Profit Pricing:

Price per Line ($)
$30,000

Nonprofit Pricing:

Price per Line ($)
$5,500

For Profit Pricing:

Price per Line (€)
€27,300

Nonprofit Pricing:

Price per Line (€)
€5,005