- Based on the phenotype reported for other Trex1 knockout mouse models, homozygous knockouts may displays inflammatory myocarditis, autoimmune disease and reduced lifespan.
Gene Description: three prime repair exonuclease 1
Gene Family:
DNA Enzyme Genetic Background:
129/SvEv-C57BL/6 Gene Accession Number:
NM_011637 Mutation Type:
Trapped Species:
Mouse The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.