Tlr3

Constitutive Knock Out

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • TF3422
    Inquire
    MGI:2156367
Gene Description: toll-like receptor 3

Gene Family:

Membrane

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_126166

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11607032
http://www.ncbi.nlm.nih.gov/pubmed/12202403
http://www.ncbi.nlm.nih.gov/pubmed/12466851
http://www.ncbi.nlm.nih.gov/pubmed/14625548
http://www.ncbi.nlm.nih.gov/pubmed/14993594
http://www.ncbi.nlm.nih.gov/pubmed/15110521
http://www.ncbi.nlm.nih.gov/pubmed/15100310
http://www.ncbi.nlm.nih.gov/pubmed/15128790
http://www.ncbi.nlm.nih.gov/pubmed/15210814
http://www.ncbi.nlm.nih.gov/pubmed/15634897
http://www.ncbi.nlm.nih.gov/pubmed/16027240
http://www.ncbi.nlm.nih.gov/pubmed/16105838
http://www.ncbi.nlm.nih.gov/pubmed/16546102
http://www.ncbi.nlm.nih.gov/pubmed/12054664
http://www.ncbi.nlm.nih.gov/pubmed/16782847
http://www.ncbi.nlm.nih.gov/pubmed/17008311
http://www.ncbi.nlm.nih.gov/pubmed/16301743
http://www.ncbi.nlm.nih.gov/pubmed/16210631
http://www.ncbi.nlm.nih.gov/pubmed/16237098
http://www.ncbi.nlm.nih.gov/pubmed/16272328
http://www.ncbi.nlm.nih.gov/pubmed/16936008
http://www.ncbi.nlm.nih.gov/pubmed/17638914
http://www.ncbi.nlm.nih.gov/pubmed/17573354
http://www.ncbi.nlm.nih.gov/pubmed/17572686
http://www.ncbi.nlm.nih.gov/pubmed/17705137
http://www.ncbi.nlm.nih.gov/pubmed/17502662
http://www.ncbi.nlm.nih.gov/pubmed/16424225
http://www.ncbi.nlm.nih.gov/pubmed/18032677
http://www.ncbi.nlm.nih.gov/pubmed/17981792
http://www.ncbi.nlm.nih.gov/pubmed/16456008
http://www.ncbi.nlm.nih.gov/pubmed/16517751
http://www.ncbi.nlm.nih.gov/pubmed/18097050
http://www.ncbi.nlm.nih.gov/pubmed/16368889
http://www.ncbi.nlm.nih.gov/pubmed/18295350
http://www.ncbi.nlm.nih.gov/pubmed/18354215
http://www.ncbi.nlm.nih.gov/pubmed/18368052
http://www.ncbi.nlm.nih.gov/pubmed/17347473
http://www.ncbi.nlm.nih.gov/pubmed/18223009
http://www.ncbi.nlm.nih.gov/pubmed/17049055
http://www.ncbi.nlm.nih.gov/pubmed/18490751
http://www.ncbi.nlm.nih.gov/pubmed/16453294
http://www.ncbi.nlm.nih.gov/pubmed/12855817
http://www.ncbi.nlm.nih.gov/pubmed/15240691
http://www.ncbi.nlm.nih.gov/pubmed/15711573
http://www.ncbi.nlm.nih.gov/pubmed/15558055
http://www.ncbi.nlm.nih.gov/pubmed/16141072
http://www.ncbi.nlm.nih.gov/pubmed/16260493
http://www.ncbi.nlm.nih.gov/pubmed/16244651
http://www.ncbi.nlm.nih.gov/pubmed/16714379
http://www.ncbi.nlm.nih.gov/pubmed/16001129
http://www.ncbi.nlm.nih.gov/pubmed/16369915
http://www.ncbi.nlm.nih.gov/pubmed/12133979
http://www.ncbi.nlm.nih.gov/pubmed/17190817
http://www.ncbi.nlm.nih.gov/pubmed/17456769
http://www.ncbi.nlm.nih.gov/pubmed/17992263
http://www.ncbi.nlm.nih.gov/pubmed/18057004
http://www.ncbi.nlm.nih.gov/pubmed/18322244
http://www.ncbi.nlm.nih.gov/pubmed/14976262
http://www.ncbi.nlm.nih.gov/pubmed/15064760
http://www.ncbi.nlm.nih.gov/pubmed/16886064
http://www.ncbi.nlm.nih.gov/pubmed/16142239
http://www.ncbi.nlm.nih.gov/pubmed/12960379

 


The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyrc-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyrc-Brd background.

For standard orders clients will receive:

  • A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed 129S5;B6 background.
  • Validated genotyping protocols
  • Animal health data

Commercial Pricing:

Number of Lines PurchasedPrice per Line ($)Price per Line for Comprehensive Phenotype Data ($)
Single Line $45,000 $25,000
2 Lines $40,500 $25,000
3 Lines $39,375 $25,000
4+ Lines $38,250 $25,000

Nonprofit Pricing:

Price per Line ($)Price per Line for Comprehensive Phenotype Data ($)
$30,000 $15,000
Basic Phenotype Package: $5,000
Multi-line discounts will be applied to lines ordered on a single purchase order (PO).

Commercial Pricing:

Number of Lines PurchasedPrice per Line (€)Price per Line for Comprehensive Phenotype Data (€)
Single Line €42,750 €23,750
2 Lines €38,475 €23,750
3 Lines €37,406 €23,750
4+ Lines €36,338 €23,750

Nonprofit Pricing:

Price per Line (€)Price per Line for Comprehensive Phenotype Data (€)
€28,500 €14,250
Basic Phenotype Package: €4,750
Multi-line discounts will be applied to lines ordered on a single purchase order (PO).