Tlr3

Gene Family:

Membrane

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_126166

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11607032 http://www.ncbi.nlm.nih.gov/pubmed/12202403 http://www.ncbi.nlm.nih.gov/pubmed/12466851 http://www.ncbi.nlm.nih.gov/pubmed/14625548 http://www.ncbi.nlm.nih.gov/pubmed/14993594 http://www.ncbi.nlm.nih.gov/pubmed/15110521 http://www.ncbi.nlm.nih.gov/pubmed/15100310 http://www.ncbi.nlm.nih.gov/pubmed/15128790 http://www.ncbi.nlm.nih.gov/pubmed/15210814 http://www.ncbi.nlm.nih.gov/pubmed/15634897 http://www.ncbi.nlm.nih.gov/pubmed/16027240 http://www.ncbi.nlm.nih.gov/pubmed/16105838 http://www.ncbi.nlm.nih.gov/pubmed/16546102 http://www.ncbi.nlm.nih.gov/pubmed/12054664 http://www.ncbi.nlm.nih.gov/pubmed/16782847 http://www.ncbi.nlm.nih.gov/pubmed/17008311 http://www.ncbi.nlm.nih.gov/pubmed/16301743 http://www.ncbi.nlm.nih.gov/pubmed/16210631 http://www.ncbi.nlm.nih.gov/pubmed/16237098 http://www.ncbi.nlm.nih.gov/pubmed/16272328 http://www.ncbi.nlm.nih.gov/pubmed/16936008 http://www.ncbi.nlm.nih.gov/pubmed/17638914 http://www.ncbi.nlm.nih.gov/pubmed/17573354 http://www.ncbi.nlm.nih.gov/pubmed/17572686 http://www.ncbi.nlm.nih.gov/pubmed/17705137 http://www.ncbi.nlm.nih.gov/pubmed/17502662 http://www.ncbi.nlm.nih.gov/pubmed/16424225 http://www.ncbi.nlm.nih.gov/pubmed/18032677 http://www.ncbi.nlm.nih.gov/pubmed/17981792 http://www.ncbi.nlm.nih.gov/pubmed/16456008 http://www.ncbi.nlm.nih.gov/pubmed/16517751 http://www.ncbi.nlm.nih.gov/pubmed/18097050 http://www.ncbi.nlm.nih.gov/pubmed/16368889 http://www.ncbi.nlm.nih.gov/pubmed/18295350 http://www.ncbi.nlm.nih.gov/pubmed/18354215 http://www.ncbi.nlm.nih.gov/pubmed/18368052 http://www.ncbi.nlm.nih.gov/pubmed/17347473 http://www.ncbi.nlm.nih.gov/pubmed/18223009 http://www.ncbi.nlm.nih.gov/pubmed/17049055 http://www.ncbi.nlm.nih.gov/pubmed/18490751 http://www.ncbi.nlm.nih.gov/pubmed/16453294 http://www.ncbi.nlm.nih.gov/pubmed/12855817 http://www.ncbi.nlm.nih.gov/pubmed/15240691 http://www.ncbi.nlm.nih.gov/pubmed/15711573 http://www.ncbi.nlm.nih.gov/pubmed/15558055 http://www.ncbi.nlm.nih.gov/pubmed/16141072 http://www.ncbi.nlm.nih.gov/pubmed/16260493 http://www.ncbi.nlm.nih.gov/pubmed/16244651 http://www.ncbi.nlm.nih.gov/pubmed/16714379 http://www.ncbi.nlm.nih.gov/pubmed/16001129 http://www.ncbi.nlm.nih.gov/pubmed/16369915 http://www.ncbi.nlm.nih.gov/pubmed/12133979 http://www.ncbi.nlm.nih.gov/pubmed/17190817 http://www.ncbi.nlm.nih.gov/pubmed/17456769 http://www.ncbi.nlm.nih.gov/pubmed/17992263 http://www.ncbi.nlm.nih.gov/pubmed/18057004 http://www.ncbi.nlm.nih.gov/pubmed/18322244 http://www.ncbi.nlm.nih.gov/pubmed/14976262 http://www.ncbi.nlm.nih.gov/pubmed/15064760 http://www.ncbi.nlm.nih.gov/pubmed/16886064 http://www.ncbi.nlm.nih.gov/pubmed/16142239 http://www.ncbi.nlm.nih.gov/pubmed/12960379

 

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.