Rtn4r

Gene Family:

Membrane

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_022982

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11201742 http://www.ncbi.nlm.nih.gov/pubmed/12378589 http://www.ncbi.nlm.nih.gov/pubmed/12466851 http://www.ncbi.nlm.nih.gov/pubmed/12839991 http://www.ncbi.nlm.nih.gov/pubmed/15647357 http://www.ncbi.nlm.nih.gov/pubmed/16452662 http://www.ncbi.nlm.nih.gov/pubmed/18043741 http://www.ncbi.nlm.nih.gov/pubmed/18337405 http://www.ncbi.nlm.nih.gov/pubmed/17470639 http://www.ncbi.nlm.nih.gov/pubmed/18214994 http://www.ncbi.nlm.nih.gov/pubmed/14614146 http://www.ncbi.nlm.nih.gov/pubmed/14664809 http://www.ncbi.nlm.nih.gov/pubmed/15121177 http://www.ncbi.nlm.nih.gov/pubmed/15504325 http://www.ncbi.nlm.nih.gov/pubmed/16195464 http://www.ncbi.nlm.nih.gov/pubmed/17122049 http://www.ncbi.nlm.nih.gov/pubmed/17572674 http://www.ncbi.nlm.nih.gov/pubmed/15866044

 

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.