Nppa

Constitutive Knockout

Cryopreserved Model
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This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • TF2586
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    MGI:97367

Gene Description: natriuretic peptide type A

Synonyms: Anf, ANP, atrial natriuretic peptide, natriuretic peptide precursor A, Pnd

Gene Family:

Membrane and Secreted

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_008725

Mutation Type:

Targeted

Species:

Mouse

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyrc-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyrc-Brd background.

For standard orders clients will receive:

  • A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed 129S5;B6 background.
  • Validated genotyping protocols
  • Animal health data

Commercial Pricing:

Number of Lines PurchasedPrice per Line ($)Price per Line for Comprehensive Phenotype Data ($)
Single Line $45,000 $25,000
2 Lines $40,500 $25,000
3 Lines $39,375 $25,000
4+ Lines $38,250 $25,000

Nonprofit Pricing:

Price per Line ($)Price per Line for Comprehensive Phenotype Data ($)
$30,000 $15,000
Basic Phenotype Package: $5,000
Multi-line discounts will be applied to lines ordered on a single purchase order (PO).

Commercial Pricing:

Number of Lines PurchasedPrice per Line (€)Price per Line for Comprehensive Phenotype Data (€)
Single Line €42,750 €23,750
2 Lines €38,475 €23,750
3 Lines €37,406 €23,750
4+ Lines €36,338 €23,750

Nonprofit Pricing:

Price per Line (€)Price per Line for Comprehensive Phenotype Data (€)
€28,500 €14,250
Basic Phenotype Package: €4,750
Multi-line discounts will be applied to lines ordered on a single purchase order (PO).