Klrk1

Gene Family:

Membrane

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_033078

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/9464811 http://www.ncbi.nlm.nih.gov/pubmed/9600963 http://www.ncbi.nlm.nih.gov/pubmed/10438936 http://www.ncbi.nlm.nih.gov/pubmed/10464175 http://www.ncbi.nlm.nih.gov/pubmed/10860661 http://www.ncbi.nlm.nih.gov/pubmed/10601355 http://www.ncbi.nlm.nih.gov/pubmed/12150888 http://www.ncbi.nlm.nih.gov/pubmed/12426564 http://www.ncbi.nlm.nih.gov/pubmed/12645935 http://www.ncbi.nlm.nih.gov/pubmed/14523385 http://www.ncbi.nlm.nih.gov/pubmed/14764662 http://www.ncbi.nlm.nih.gov/pubmed/15238421 http://www.ncbi.nlm.nih.gov/pubmed/15328154 http://www.ncbi.nlm.nih.gov/pubmed/15746162 http://www.ncbi.nlm.nih.gov/pubmed/16116470 http://www.ncbi.nlm.nih.gov/pubmed/16002667 http://www.ncbi.nlm.nih.gov/pubmed/16470377 http://www.ncbi.nlm.nih.gov/pubmed/16973387 http://www.ncbi.nlm.nih.gov/pubmed/16914326 http://www.ncbi.nlm.nih.gov/pubmed/16619285 http://www.ncbi.nlm.nih.gov/pubmed/17548517 http://www.ncbi.nlm.nih.gov/pubmed/18209064 http://www.ncbi.nlm.nih.gov/pubmed/18198346 http://www.ncbi.nlm.nih.gov/pubmed/14707119 http://www.ncbi.nlm.nih.gov/pubmed/16141072 http://www.ncbi.nlm.nih.gov/pubmed/15878887 http://www.ncbi.nlm.nih.gov/pubmed/16116168 http://www.ncbi.nlm.nih.gov/pubmed/16323246 http://www.ncbi.nlm.nih.gov/pubmed/17463084 http://www.ncbi.nlm.nih.gov/pubmed/16086018 http://www.ncbi.nlm.nih.gov/pubmed/17952078 http://www.ncbi.nlm.nih.gov/pubmed/18394936 http://www.ncbi.nlm.nih.gov/pubmed/16623599

 

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.