Fgf23

Gene Family:

Secreted

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_022657

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11062477 http://www.ncbi.nlm.nih.gov/pubmed/12032146 http://www.ncbi.nlm.nih.gov/pubmed/12466851 http://www.ncbi.nlm.nih.gov/pubmed/12791601 http://www.ncbi.nlm.nih.gov/pubmed/15579309 http://www.ncbi.nlm.nih.gov/pubmed/16123981 http://www.ncbi.nlm.nih.gov/pubmed/15531762 http://www.ncbi.nlm.nih.gov/pubmed/16436388 http://www.ncbi.nlm.nih.gov/pubmed/17148678 http://www.ncbi.nlm.nih.gov/pubmed/17174939 http://www.ncbi.nlm.nih.gov/pubmed/17123805 http://www.ncbi.nlm.nih.gov/pubmed/17848631 http://www.ncbi.nlm.nih.gov/pubmed/17942069 http://www.ncbi.nlm.nih.gov/pubmed/11900978 http://www.ncbi.nlm.nih.gov/pubmed/16141072 http://www.ncbi.nlm.nih.gov/pubmed/16436465 http://www.ncbi.nlm.nih.gov/pubmed/16449303 http://www.ncbi.nlm.nih.gov/pubmed/16597685 http://www.ncbi.nlm.nih.gov/pubmed/14966565

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.