Cacna1c

Constitutive Knockout

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CALL: 888.822.6642 + 45 70 23 04 05 (EUROPE and DENMARK) +49 214 50 68 023 (GERMANY)

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This line is cryopreserved and requires cryorecovery.

Model #
Genotype
Nomenclature

TF1589

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MGI:103013

Model Description

Gene Description: calcium channel, voltage-dependent, L type, alpha 1C subunit

Synonyms: (alpha)1 subunit, Cav1.2, Cchl1a1, D930026N18Rik, L-type Cav1.2

Gene Family:

Ion Channel

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_009781

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/1385406
http://www.ncbi.nlm.nih.gov/pubmed/1335956
http://www.ncbi.nlm.nih.gov/pubmed/7814415
http://www.ncbi.nlm.nih.gov/pubmed/2173707
http://www.ncbi.nlm.nih.gov/pubmed/7598723
http://www.ncbi.nlm.nih.gov/pubmed/76351

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

Mutation Image

Deliverables

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.

For standard orders clients will receive:

A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background.
Validated genotyping protocols
Animal health data

Terms of Sale

Terms of Sale for the Knockout Repository:

Terms of Sale for Phenotypic Data Packages (Basic and Comprehensive):

Pricing

Business Type	Price per Line $/€	Price per Line for Comprehensive Phenotype Data $/€
For Profit (Commercial)	$24,000 €21,000	$10,000 €9,100
Nonprofit	$17,500 €15,500	$8,000 €7,280

Basic Phenotype Package: $5,000/€4,550

KOR models are invoiced upon shipment. Once orders are placed, full purchase price will be applied if order is cancelled.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.