Apoa5

Gene Family:

Secreted

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_080434

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11217851
http://www.ncbi.nlm.nih.gov/pubmed/11588264
http://www.ncbi.nlm.nih.gov/pubmed/11577099
http://www.ncbi.nlm.nih.gov/pubmed/12466851
http://www.ncbi.nlm.nih.gov/pubmed/14974682
http://www.ncbi.nlm.nih.gov/pubmed/14983036
http://www.ncbi.nlm.nih.gov/pubmed/12810823
http://www.ncbi.nlm.nih.gov/pubmed/15774484
http://www.ncbi.nlm.nih.gov/pubmed/15117734
http://www.ncbi.nlm.nih.gov/pubmed/16498401
http://www.ncbi.nlm.nih.gov/pubmed/16166565
http://www.ncbi.nlm.nih.gov/pubmed/17916774
http://www.ncbi.nlm.nih.gov/pubmed/18056685

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.