Adh5

Constitutive Knockout

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CALL: 888.822.6642 + 45 70 23 04 05 (EUROPE and DENMARK) +49 214 50 68 023 (GERMANY)

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This line is cryopreserved and requires cryorecovery.

Model #
Genotype
Nomenclature

TF2543

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MGI:87929

Model Description

Gene Description: alcohol dehydrogenase 5 (class III), chi polypeptide

Synonyms: Adh3, Adh-5, GSNOR, S-nitrosoglutathione reductase

Gene Family:

Enzyme

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_007410

Mutation Type:

Trapped

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/3996732
http://www.ncbi.nlm.nih.gov/pubmed/7738026
http://www.ncbi.nlm.nih.gov/pubmed/8621625
http://www.ncbi.nlm.nih.gov/pubmed/8647091
http://www.ncbi.nlm.nih.gov/pubmed/8892527
http://www.ncbi.nlm.nih.gov/pubmed/11217

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

Mutation Image

Deliverables

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.

For standard orders clients will receive:

A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background.
Validated genotyping protocols
Animal health data

Terms of Sale

Terms of Sale for the Knockout Repository:

Terms of Sale for Phenotypic Data Packages (Basic and Comprehensive):

Pricing

Business Type	Price per Line $/€	Price per Line for Comprehensive Phenotype Data $/€
For Profit (Commercial)	$24,000 €21,000	$10,000 €9,100
Nonprofit	$17,500 €15,500	$8,000 €7,280

Basic Phenotype Package: $5,000/€4,550

KOR models are invoiced upon shipment. Once orders are placed, full purchase price will be applied if order is cancelled.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.