Adam33

Gene Family:

Protease

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_033615

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/10086356
http://www.ncbi.nlm.nih.gov/pubmed/11814695
http://www.ncbi.nlm.nih.gov/pubmed/12466851
http://www.ncbi.nlm.nih.gov/pubmed/15063736
http://www.ncbi.nlm.nih.gov/pubmed/12972401
http://www.ncbi.nlm.nih.gov/pubmed/15657107
http://www.ncbi.nlm.nih.gov/pubmed/11897009
http://www.ncbi.nlm.nih.gov/pubmed/16141072
http://www.ncbi.nlm.nih.gov/pubmed/16079176
http://www.ncbi.nlm.nih.gov/pubmed/16943435
http://www.ncbi.nlm.nih.gov/pubmed/12110844

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.