Neuroscience Portfolio

Easy Access to Relevant Models for Key Applications

Neuroscience Portfolio A major challenge in neuroscience research and drug discovery is the lack of easy access to relevant animal models for use in screening drug candidates. Taconic Biosciences' Neuroscience Portfolio provides easy access to models and services for the study of neuronal disease and signaling, many of which are available exclusively from Taconic with rights to use.

Together with scientific support from PhD scientists, extensive phenotyping data, and our customized breeding and aging services, we help you accelerate your neuroscience research efforts.

Which specific disease area are you studying?

  • Alzheimer's Disease Models - Taconic offers a variety of transgenic rodent models that develop plaques and tangles and allow screening of novel drug candidates for treatments against Alzheimer’s and other neurodegenerative diseases.
  • Parkinson's Disease Models - Taconic offers several Parkinson's models (sponsored by The Michael J fox Foundation) as well as a surgically induced model that can be used as tools to develop therapies against Parkinson's Disease.
  • Neuropsychiatric Disorder Models - Taconic offers three neuropsychiatric disorder animal models that develop distinct neurological and behavioral phenotypes. These models can be used to screen novel drug candidates for treating schizophrenia, autism spectrum disorders, epilepsy, and other neuropsychiatric disorders.
  • Amyotrophic Lateral Sclerosis (ALS) Disease Model - Taconic offers a humanized animal model, the SOD1 G93A Rat, sponsored by the ALS Association, that allows you to screen novel compounds for efficacy against the pathologies associated with ALS (Lou Gehrig’s disease).
  • CRE-Luc GPCR Reporter Mouse Platform - Taconic offers a panel of luciferase reporter mice to assay GPCR ligand binding and pathway activation in various tissues. Mice with CNS specific expression of CRE-Luc reporter can be used to isolate primary neurons (for in vitro studies) or for in vivo imaging studies to assay GPCR based signaling in the CNS. This platform can also provide rapid in vivo PK/PD profiling of compounds with quantitative data to compare pharmacological action.
  • Central Nervous System Trauma Model - Taconic offers the GFAP-Luc mouse which carries a luciferase reporter gene under the control of the GFAP promoter and provides an easy to use tool to study CNS damage. The reporter is inducible following injury to the CNS and the model is useful for studying changes in the health of the CNS.
  • Brain Inflammation Model - Taconic offers several models for use in Experimental Autoimmune Encephalomyelitis (EAE), which is widely studied as an animal model of CNS demyelinating diseases, including Multiple Sclerosis (MS) and acute disseminated encephalomyelitis.

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