Comparison Guide: huNOG-EXL, NSG-SGM3 and MISTRG

Megan M. MacBride, PhD
Friday, April 3rd, 2020
Several super immunodeficient models expressing cytokines designed to drive myeloid cell lineage commitment have been generated. The most advanced cytokine transgenic mouse models are the huNOG-EXL, NSG-SGM3 and the MISTRG. This group of models has promise to improve human immune system engraftment in mice, but each one has different features which must be considered when choosing an experimental model.

Each model expresses two or more human variants of key cytokines that otherwise limit myeloid differentiation due to cross species differences. Explore the features of each model in the comparison table.

Questions remain over survival and availability

In general, all three models develop higher levels of human cell chimerism in the peripheral blood after HSC engraftment compared to the base strains or stocks (NOG, NSG or Rag2/Il2rg knockout).

Limitations exist for these next generation models. Typically, survival of the graft and/or mouse is limited compared to the base strain/stock. In addition not all lines are available to all users at this time.

Use the chart below to compare the three models and select the most appropriate one for your study.

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