Line 10678 was developed in the laboratory of Chenjian Li at Cornell. The model was created through pronuclear injection of human gene SNCA with the A53T mutation into NTac:SD zygotes. Founder line 268 was bred to NTac:SD. The colony is maintained by mating a wild type female with a hemizygous male to produce hemizygous pups. Taconic received stock from Cornell in 2010 and derived the rats through embryo transfer derivation.
Initial characterization of this model is in progress.
Rats may be cryo-recovered at Taconic. Nonprofit users may access rats for research purposes under a simple label license (no signatures required). For-profit users must first execute a license agreement with Cornell University.
Conditions of Use for Parkinson's Disease Rat Models for Nonprofit Users:
For licensing information, contact:
Cornell Center for Technology Enterprise and Commercialization
Attention: Executive Director
395 Pine Tree Road, Suite 310
Ithaca, NY 14850
Cite: Docket D4184 (LRRK2) and D5203 (alpha-synuclein)