Slc22a6 - Slc22a8 - Model 9329 - KO

This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 9329
    C57BL/6-Del(Slc22a6-Slc22a8)tm1.2 Mrl
  • The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
  • Slc22a6 exon 1 contains the translation initiation codon.
  • Slc22a8 exon 2 contains the translation initiation codon.
  • Exons 3-11 of Slc22a8 and exons 1-9 of Slc22a6 have been deleted by homologous recombination.
  • The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The constitutive KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
  • Deletion of exons 3-11 of Slc22a8 and exons 1-9 of Slc22a6 should result in loss of function of the Slc22a6 and Slc22a8 genes by deleting the Major facilitator superfamily domain of both genes.
  • The remaining recombination sites are located in intron regions of the genome.
  • Data mining and Design performed in 2006.

Gene Family:

Solute carrier

Gene Symbol:


Gene Accession Number:

NM_008766, NM_001164634

Allele Type:



Mouse Clinical Institute (MCI)



Official Gene Name:

solute carrier family 22 (organic anion transporter), member 6-8

GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

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