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Elovl1 - Model 10906 - cKO

Conditional Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 10906
    C57BL/6-Elovl1<tm1.1 Mrl>
  • The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
  • Exon 2 contains the translation initiation codon.
  • Exons 2 to 8 have been flanked by loxP sites (size of loxP-flanked region: 2.4 kb).
  • The conditional KO allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
  • The conditional KO line has been derived using C57BL/6NTac animals and the Flp-transgene was removed by segregation.
  • The constitutive KO allele can be generated by Cre-mediated recombination. Deletion of exons 2 to 8 should result in loss of function of the Elovl1 gene by deleting the complete ORF
  • According to NCBI and Ensembl databases, the Cdc20 gene (Entrez ID: 107995; ENSMUSG0000006398) is located downstream of Elovl1 in a tail-to-tail orientation. The 3´ UTR of Elovl1 gene overlaps with the 3´ UTR of Cdc20 (40 bp). Therefore, the distal LoxP site has to be inserted within Cdc20 exon 10 and would interfere with normal expression and stability of Cdc20 mRNA. In order to restore Cdc20 exon 10, 241 bp encompassing the overlapping 3´ UTR region has been duplicated in the targeting vector.
  • Datamining and Design performed in 2009.

Gene Family:


Genetic Background:


Gene Symbol:


Gene Accession Number:


Allele Type:





Cryopreserved at Taconic



Official Gene Name:

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1

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GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.