CRE-Luc GPCR Reporter Mouse, Line 11

Random Transgenic

Cryopreserved CRE-Luc GPCR Reporter Mouse, Line 11 - Taconic Biosciences
EZcohort® Models
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This model is available for immediate cryorecovery.

FVB Background

  • Model #
  • Genotype
  • Nomenclature
  • 11515
  • Expresses luciferase under the control of the cAMP response element (CRE)
  • GPCR signaling through the cAMP pathway can be detected from the target. GPCR that is in a native cellular environment with a full complement of associated receptors and membrane constituents
  • Luciferase is expressed primarily in the pancreas in Line 11
  • Useful for screening in vivo, in vitro, and ex vivo using whole animals, tissues, and primary cells
  • Learn more about the CRE-Luc GPCR Reporter Mouse Platform
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

FVB Background


The CRE-Luc GPCR Reporter Mouse, Line 11 was developed by Sanofi. The model was created by microinjecting a transgene containing a 6x CRE promoter, the HSV TK minimal promoter, modified firefly luciferase cDNA from pGL4 and a human growth hormone polyA tail. This transgene was microinjected into FVB/NTac zygotes. The resultant mice from founder line 11 were bred to FVB/NTac mice. Taconic received stock from Sanofi in 2012. The line was embryo transfer derived. In the production colony, the line was maintained by mating homozygous males and females.





Initial Publication:

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