CRE-Luc GPCR Reporter Mouse, Line 11

Random Transgenic

Cryopreserved CRE-Luc GPCR Reporter Mouse, Line 11 - Taconic Biosciences
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This model is available for immediate cryorecovery.

FVB Background

  • Model #
  • Genotype
  • Nomenclature
  • 11515
    FVB/NTac-Tg(CRE/Tk-luc)11Hgp
  • Expresses luciferase under the control of the cAMP response element (CRE)
  • GPCR signaling through the cAMP pathway can be detected from the target. GPCR that is in a native cellular environment with a full complement of associated receptors and membrane constituents
  • Luciferase is expressed primarily in the pancreas in Line 11
  • Useful for screening in vivo, in vitro, and ex vivo using whole animals, tissues, and primary cells
  • Learn more about the CRE-Luc GPCR Reporter Mouse Platform
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

FVB Background

Origin:

The CRE-Luc GPCR Reporter Mouse, Line 11 was developed by Sanofi. The model was created by microinjecting a transgene containing a 6x CRE promoter, the HSV TK minimal promoter, modified firefly luciferase cDNA from pGL4 and a human growth hormone polyA tail. This transgene was microinjected into FVB/NTac zygotes. The resultant mice from founder line 11 were bred to FVB/NTac mice. Taconic received stock from Sanofi in 2012. The line was embryo transfer derived. In the production colony, the line was maintained by mating homozygous males and females.

Color:

Albino

Species:

Mouse

Initial Publication:



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This model is sold under terms which grant perpetual use rights.