Genetically Modified Mouse Models: From Generation to Colony Management in Accordance with the 3Rs

Talk #1: Minimize the use of mice in preclinical research by choosing the right mouse model.

Speaker: Ditte Olsen, PhD - (30')  
Field Applications Scientist

The success rate of translating preclinical findings into clinical treatments is estimated to be less than 10%. This phenomenon is commonly referred to as the “valley of death” in translational research. The challenge of translatability is caused by several factors including, biological differences between animal models and humans, reproducibility issues, poor model selection and statistical and methodological flaws.

This presentation will focus on the significance of choosing the right mouse model, highlighting the importance of genetic background and phenotypic relevance to optimize experimental design which are crucial for the success and ethical integrity of biomedical research and to conduct animal studies in a manner that follows the 3R principles.

Talk #2: Existing tools for Customized Models Generation Solution – pros & cons about the different methodologies.

Speaker: Benedikt Wefers, PhD - (30')  
Scientific Program Manager, Custom Model Generation Solutions

Genetically engineered animal models are important tools for both academic fundamental research, as well as in pharmaceutical and biotechnological applications. Due to steady advances in gene targeting, increasingly sophisticated and highly customized models can be generated. In this presentation we will discuss the three major methods to generate these customized models and will focus on their specific advantages and on their limitations & drawbacks. Choosing the correct methodology is not only important for efficient and cost-effective generation of experimental models but is also key in the reduction of sur-plus animals in the sense of the 3Rs.

Talk #3: Optimized colony management solutions with respect to the 3 R’s.

Speaker: Julie Torvund-Jensen, PhD – (30‘) 
Scientific Program Manager, Scientific Services

A growing focus on animal welfare and the 3 R’s, combined with increasingly strict regulations for animal euthanasia creates a need for optimized colony management solutions. Balancing the need for easily accessible study animals while limiting animal wastage can be challenging and requires meticulous planning. During this presentation we will present the available tools for optimized colony management with respect to the 3 R’s.