Stat1

Genetic Background:

129S6 Background

Origin:

The Stat1 mouse was developed in the laboratory of Robert Schreiber at the Washington University School of Medicine. The model was created by targeting the Stat1 gene in GS-1 ES cells and injecting the targeted cells into blastocysts. Heterozygotes for the mutation were produced from the chimeras and intercrossed to generate homozygotes. Taconic received stock in 1997. The mice were embryo transfer derived. The original Stat1 model (000679-M) differed from the Taconic 129S6 at two biochemical loci, Pgm1 and Gpi1. In January 2002, the original Stat1 line was backcrossed to the Taconic 129S6/SvEvTac, and animals were selected to match the Pgm1c and Gpi1b alleles of the 129S6. The selected heterozygotes were intercrossed to homozygosity. The line is maintained through incrossing of homozygous mice. This improvement makes the 129S6/SvEvTac a more perfectly matched control for the Stat1 model.

Genetics:

Wild type for Nnt mutation

Color:

White-Bellied Black Agouti

Species:

Mouse

Initial Publication:

Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD. (1996) Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell, 84(3):431-442.

Animal Diet:

NIH #31M Rodent Diet

Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

• Title to these Models and biological materials derived from them remains with Taconic.
• The Models will be used for research purposes only.
• The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
• The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
• Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

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