Learn more about engrafted human immune models and their impact for allergy, inflammation and immuno-oncology research.
The development of animal models capable of mimicking human immune responses is crucial to study the pathophysiology of disease and to generate new therapeutic methodologies. Significant advances in immunology modeling have been made utilizing the super immune-deficient CIEA NOG mouse®, but the full application of engrafted human immune models depends upon overcoming some cross-species differences.
Topics DiscussedThis webinar provided insights on the current state of immune system engraftment and additional information on:
- Methodologies and best practices employed for immune system engraftment.
- Strengths and limitations of current human immune system engraftment technologies and the latest products providing innovative solutions.
- Applications of huNOG-EXL human immune system models in allergy, inflammation, and immuno-oncology.
- Biological underpinnings of hematopoietic lineage commitment in NOG and NOG-EXL mice.