Humanized Immune System Mice

Taconic Biosciences uniquely combines access to a robust humanized immune system (HIS) mouse model portfolio with application expertise to maximize experimental success. Taconic offers key HIS models along with next-generation host strains for in-house humanization. Selection of the right HIS model starts with consideration of the human cell type(s) of interest.

The Taconic NOG Portfolio of super immunodeficient and humanized immune system mouse models

image showing the Taconic NOG Portfolio of super Immunodeficient and Humanized Immune System Mouse models

Easiest Access to Commercial Humanized Mice

Start projects sooner with immediate off the shelf inventory available within days and not months. Additionally, Taconic's humanized immune system mice, including the next-generation CIEA NOG mouse® models, are distributed with no additional licensing requirements under clear for-profit terms of use and nonprofit terms of use. Taconic Biosciences is the only rodent model provider empowering customers to obtain models without an MTA or commercial use license.

A Portfolio of Humanized Mouse Model Solutions

Taconic's NOG mice are severely immunodeficient mouse models which accept the engraftment of heterologous cells more readily than traditional immunodeficient models, making them exceptional hosts for the production of mice with human immune systems.

Study-ready Humanized Immune System Mice

Taconic offers five well-characterized human immune system models:

  1. huNOG: NOG mice engrafted with human CD34+ hematopoietic stem cells (HSCs).
  2. huPBMC-NOG: Made-to-order human peripheral blood mononuclear cell (PBMC) engrafted mice. PBMC-humanized mice are optimally suited short term efficacy studies and for Graft vs. Host Disease (GvHD) studies.
  3. huPBMC-B2m-NOG: Made-to-order human peripheral blood mononuclear cell (PBMC) engrafted mice using the B2m-NOG as host. Compared to NOG, B2m-NOG mice have markedly delayed GvHD onset after human PBMC engraftment, providing an expanded study window (8+ weeks). This vastly increases the utility of the model in immuno-oncology experiments.
  4. huNOG-EXL SA and huNOG-EXL EA: huNOG-EXL mice have more complete human immune reconstitution, with both lymphoid and myeloid lineages. Next-generation NOG mice, expressing human cytokines that enhance immune system humanization, engrafted with CD34+ HSCs, and available at study-ready ages and quantities. Compare huNOG-EXL options offered by Taconic Biosciences.
  5. FcResolv™ huNOG: A humanized immune system (HIS) mouse designed for more accurate assessment of antibody-based drugs. Made through engraftment of CD34+ HSCs into FcResolv™ NOG mice, which lack certain murine Fc receptors that can otherwise confound experimental results.
Challenges in Models of Myeloid Cell Engrafthment in Humanized MiceLearn more about how huNOG-EXL SA compares to other models for myeloid cell engraftment in our Insight:

Next-Generation Host Strains for Humanization

Next-generation NOG Portfolio strains incorporate genetic humanizations to support improved engraftment of certain human cell types or other genetic modifications for improved engraftment.

  1. NOG-EXL (hGM-CSF/hIL-3 NOG): NOG mice capable of enhancing human myeloid cell engraftment through the transgenic expression of human GM-CSF and human IL-3.
  2. B2m-NOG: NOG mice with an additional knockout of the B2m gene which disrupts MHC class I antigen presentation; compared to NOG mice, B2m-NOG mice have markedly delayed GvHD onset after human PBMC engraftment.
  3. hIL-2 NOG: Super-immunodeficient NOG mice expressing transgenic human IL-2 cytokine to enhance human T cell function.
  4. hIL-6 NOG: IL-6 cytokine-expressing humanized mouse models with multiple applications in cancer and immunology research.
  5. hIL-15 NOG: NOG mice expressing human IL-15 cytokines, supporting enhanced human NK cell engraftment for applications in the assessment of antibody therapeutics and cell cytotoxicity.
  6. FcResolv™ NOG: NOG mice with reduced residual murine immune activity through functional knock out of mouse FcγRs. Suitable for similar applications as the CIEA NOG mouse®, including tumor xenografts using cell lines or patient-derived tumors, engraftment of other normal or pathological human cells and tissues, and immune system humanization studies.
  7. FcResolv™ hIL-15 NOG: hIL-15 NOG mice with reduced residual murine immune activity through functional knock out of mouse FcγRs. Suitable for similar applications as the hIL-15 NOG, including efficacy studies on antibody-based therapeutics with an ADCC mechanism of action.
  8. TK-NOG: NOG mice with transgenic expression of thymidine kinase under control of liver-restricted albumin promoter to facilitate hepatocyte humanization.

HIS Model Experts to Drive Success

The correct application of research tools can be just as vital as the tools themselves in driving success. Taconic's PhD Field Application Scientists are a critical resource in delivering the best humanized model solution.

Only Taconic's Field Application Scientists can support customers with:

  • HIS mouse model selection and technical consultations
  • Experimental study design
  • Establishing collaborations that de-risk development of HIS mouse applications
  • Identification of contract service providers with relevant model expertise and experience


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