Humanized Mice

For drug discovery researchers seeking the most translatable models available, Taconic Biosciences uniquely combines access to a robust humanized mouse model portfolio with application expertise to ensure correct study design.

Hematopoiesis and Human Immune System Engrafted Mice


Hematopoiesis and Human Immune System Engrafted Mice

Easiest Access to Commercial Humanized Mice

 Access means researchers can start projects sooner, with immediate, off the shelf inventory, providing models within days and not months. Additionally, Taconic's humanized immune system mice, including the next-generation CIEA NOG mouse® models, are distributed with no additional licensing requirements under clear for-profit terms of use and non-profit terms of use. Taconic Biosciences is the only rodent model provider empowering customers to obtain models without an MTA or commercial use license.

A Portfolio of Humanized Mouse Model Solutions

 Taconic's NOG mice are severely immunodeficient mouse models which accept the engraftment of heterologous cells more readily than traditional immunodeficient models, making them exceptional hosts for the production of mice with human immune systems.

Study-ready Humanized Immune System Mice

Taconic offers three well-characterized strains of human immune system-engrafted mice:

  1. huNOG: NOG mice engrafted with human CD34+ hematopoietic stem cells (HSCs) and available at study-ready ages and quantities.
  2. huPBMC-NOG: Made-to-order human peripheral blood mononuclear cell (PBMC) engrafted mice. PBMC-humanized mice are optimally suited for Graft vs. Host Disease (GvHD) studies and as a screening system for T cell modulating drugs.
  3. huNOG-EXL: A next-generation NOG mouse, expressing human cytokines that enhance immune system humanization, engrafted with CD34+ HSCs, and available at study-ready ages and quantities.

Next-Generation Host Models for Humanization

Next-generation humanized mouse models are based on the core NOG portfolio and contain genetic humanizations for generating advanced mice with human immune systems, humanized PDX models, and more.

Taconic currently offers five strains of next-generation humanized mice, with additional models undergoing development and characterization:

  1. NOG-EXL (hGM-CSF/hIL-3 NOG): NOG mice capable of enhancing human myeloid cell engraftment through the transgenic expression of human GM-CSF and human IL-3.
  2. hIL-2 NOG: Super-immunodeficient NOG mice expressing transgenic human IL-2 cytokine to enhance human T cell function.
  3. hIL-6 NOG: IL-6 cytokine-expressing humanized mouse models with multiple applications in cancer and immunology research.
  4. hIL-15 NOG: NOG mice expressing human IL-15 cytokines, supporting enhanced human NK cell engraftment for applications in the assessment of antibody therapeutics and cell cytotoxicity.
  5. TK-NOG: NOG mice with transgenic expression of thymidine kinase under control of liver-restricted albumin promoter to facilitate hepatocyte humanization.

Humanized Mouse Model Experts to Drive Success

 The correct application of research tools can be just as vital as the tools themselves in driving success. Taconic's PhD Field Application Scientists are a critical resource in delivering the best humanized model solution.

Only Taconic's Field Application Scientists can support customers with:

  • Humanized mouse model selection and technical consultations
  • Experimental study design and humanized model implementation
  • Establishing collaborations that de-risk development of humanized mouse applications
  • Identification of contract service providers with relevant humanized model expertise and experience
Contact Taconic Biosciences Learn more about how a Taconic Field Application Scientist can help you with your Humanized Mice needs: