In a recent article published in the Journal of Precision Medicine, Taconic Biosciences' scientists Dr. Philip Dubé, Dr. Ivan Gladwyn-Ng, and Dr. Janell Richardson explain three different humanization strategies for creating mouse models for preclinical research. In the first part of this series, the authors discussed the benefits of HIS mice, humanized GEMs, and humanized microbiome mice, HMM. In this article, the critical considerations for all three techniques are reviewed:
"Humanization strategies in preclinical research enable greater translational potential and expanded opportunities for therapeutic evaluation. Mouse models can be humanized by either engrafting a human immune system (HIS mice), inserting a human gene into the mouse genome (humanized GEM), or tailoring the mouse microbiome (humanized microbiome mice, HMM). In the first part of this series, we provided an overview of the strengths and considerations for each of these three strategies. Here, we discuss the critical considerations for each and the various applications for humanized models in immuno-oncology research."
Read the full article at: thejournalofprecisionmedicine.com
Taconic has multiple humanized mouse models available for preclinical research.
"Humanization strategies in preclinical research enable greater translational potential and expanded opportunities for therapeutic evaluation. Mouse models can be humanized by either engrafting a human immune system (HIS mice), inserting a human gene into the mouse genome (humanized GEM), or tailoring the mouse microbiome (humanized microbiome mice, HMM). In the first part of this series, we provided an overview of the strengths and considerations for each of these three strategies. Here, we discuss the critical considerations for each and the various applications for humanized models in immuno-oncology research."
Taconic has multiple humanized mouse models available for preclinical research.