The hTH-GFP rat was developed in collaboration between The Michael J. Fox Foundation, Thomas Jefferson University, and Taconic. DNA fragments including 10.794 kb of the distal hTH promoter and 1.168 kb of proximal hTH promoter were ligated and placed upstream of the GFP reporter gene to create the hTH-GFP construct. The model was created through pronuclear injection of the hTH-GFP construct into NTac:SD zygotes. Founder line 12141 was bred to NTac:SD. The colony is maintained by mating transgenic females with SD:NTac males.
Iacovitti L, Wei X, Cai J, Kostuk EW, Lin R, Gorodinsky A, Roman P, Kusek G, Das SS, Dufour A, Dave KD. (2013) The hTH-GFP Rat: A Novel Model for the Study of Parkinson's Disease; poster 329.12/I11 presented at the society for Neuroscience Annual Meeting 2013, San Diego, CA.
The hTH-GFP Rat Model may be purchased by for-profit or non-profit users under the following label license (no signatures required).
LABEL LICENSE AGREEMENT FOR hTH-GFP RAT