The B10.Q congenic strain was originally developed for use in transplantation studies. More recently it has been discovered that there are important immunological differences between the JAX sub-line, B10.D1-H2q/SgJ and the NIAID sub-line B10.D1/-H2q/SgAi. Since their separation, the B10.D1-H2q/SgJ line has acquired a genetic defect which altered its immune phenotype. While B10.D1-H2q/SgJ has been shown to be resistant to the induction of autoimmune arthritis, the NIAID subline has remained susceptible.
Origin:
The B10.Q congenic was made at the Jackson Laboratory by Dr. Jack Stimpfling . When Stimpfling relocated to Montana he took a colony of the B10.Q line with him, and in 1975, this subline was acquired by Dr. Ron Schwartz at NIAID.
Availability:
This model is no longer available. Color:
Black Species:
Mouse Initial Publication:
Shaw M, Boyartchuk V, Wong S, Karaghiosoff M, Ragimbeau J, Pellegrini S, Muller M, Dietrich W and Yap G. A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity. PNAS 2003 100: 11594-11599
