Alzheimer's Disease Models
Amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) combined with deficits in learning and memory are hallmarks of Alzheimer’s Disease (AD).
Understanding how plaques and tangles are formed and discovering effective therapeutics that prevent these neurodegenerative processes are important factors for winning the
battle against Alzheimer’s Disease.
As part of Taconic's
Neuroscience Portfolio, we offer a variety of transgenic rodent models that
develop plaques and tangles and allow screening of novel drug candidates for treatments against Alzheimer’s and other neurodegenerative diseases.
What our customers say:
“Cure Alzheimer's Fund is working closely with Taconic on our Genes to Therapies program, which supports investigations of gene variants impacting risk of Alzheimer's through funded research and the development of specialized genetically engineered mouse strains. The team at Taconic has provided excellent project management and technical support and are vital partners for the success of a complex project involving many custom strains and academic research labs.”
Cure Alzheimer's Fund What our customers say:
“Taconic Biosciences has been an invaluable resource for the entire Alzheimer's disease (AD) research community. As an academic researcher that builds animal models of sporadic AD I cannot possibly supply the communities needs for these models but instead depend on Taconic to fulfill this role. My hope is that as new and improved models become characterized and validated that the research community at large will supply these models to Taconic to manage and distribute.”
Patrick Sullivan, PhD, Associate Professor of Geriatrics at major university 
Learn more about:
View a
timeline of neuropathology of these mouse models as well as amyloid plaque development in the APPSWE mouse brain.
Learn about the
benefits of using sporadic AD mouse models for studying the role of human APOE polymorphism neurodegenerative disorders.
