Alzheimer's Disease Models

Amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) combined with deficits in learning and memory are hallmarks of Alzheimer’s Disease (AD). Understanding how plaques and tangles are formed and discovering effective therapeutics that prevent these neurodegenerative processes are important factors for winning the battle against Alzheimer’s Disease.

As part of Taconic's Neuroscience Portfolio, we offer a variety of transgenic rodent models that develop plaques and tangles and allow screening of novel drug candidates for treatments against Alzheimer’s and other neurodegenerative diseases.

Familial AD Models:

View a timeline of neuropathology of these mouse models as well as amyloid plaque development in the APPSWE mouse brain.

Sporadic AD Models:

Learn about the benefits of using sporadic AD mouse models for studying the role of human APOE polymorphism neurodegenerative disorders.

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