Standard Immunodeficients

Immunodeficient models have contributed to major scientific advances in immunology, transplantation, oncology, stem cell research, and infectious disease therapies. Taconic Biosciences is proud to offer a wide variety of immunodeficient rodent models that can be supplied quickly and efficiently to help propel your research forward.

What our customers say:

“The MRC Mary Lyon Centre located at MRC Harwell uses Taconic's inbred mouse lines (specifically C57BL/6NTac) to generate and characterize new mouse models for use in individual research projects, including high-throughput international programs and genome editing efforts.”

MRC Harwell

What our customers say:

“Hooke uses the Taconic B6 because we get more consistent disease development for Experimental Autoimmune Encephalomyelitis (EAE) then when using mice from other vendors.”

Hooke Laboratories

Mice

B6 nude (cryopreserved)
BALB/c nude (cryopreserved)
NOD scid (cryopreserved)
Swiss nude (cryopreserved)
Diabetic (cryopreserved)

Rats

NIH Nude

Additional GEM Immunodeficient Strains

The standard immunodeficient strains and stocks above have broad applications, are generally produced from sizeable live colonies and are available under Taconic's general terms of sale. Taconic offers additional genetically engineered (GEM) immunodeficient models which may have specialty applications and which are subject to more restrictive terms of use. Use the comparison table below or contact Taconic for guidance on the most appropriate immunodeficient model for your needs.

KEY

Black & White Nude

Black Nude

Albino Nude

Black

Albino

T Cell Deficient

B Cell Deficient

NK Cell Deficient

Certain cell lines engraft easily in nude or scid mice, but slow-growing cell lines and patient-derived tumors may require super immunodeficient hosts such as NOG mice. NOG and second generation NOG strains are also appropriate hosts for immune system humanization, and these models can be further engrafted with human tumors to study immuno-oncology therapeutic efficacy.

Taconic has compiled a database of published human tumor cell lines, with details on cancer type, appropriate host strains and published references. This is an excellent starting point for identification of desired cell lines, likely hosts and starting conditions for a pilot study. Not sure which strain may be best for your study? Contact us for a free trial, including comparison of multiple host strains.

Model#	Model Name	Other Immunodeficiencies
NCRNU	NCr nude mouse
NMRINU	NMRI nude mouse
NIHRNU	NIH nude rat
1147	Jh (BALB/c) mouse
17758	Jh (C57BL/6) mouse
CB17SC	C.B-17 scid mouse
ICRSC	ICR scid mouse
601	Rag2 (BALB/c) mouse
RAGN12	Rag2 (C57BL/6) mouse
CBSCBG	Scid-beige mouse
4111	Rag2/II2rg Double Knockout mouse (C57BL/6)	Dysfunctional dendritic cells
11503	CIEA BRG mouse (BALB/c)	Dysfunctional dendritic cells
NOG	CIEA NOG mouse®	Reduced complement activity, dysfunctional macrophages & dendritic cells, deficiencies in immune signaling, including cytokine production. The most Immune deficient mouse available

Cryopreserved standard strains may be obtained faster and less expensively from another vendor which maintains live breeding. Taconic retains webpages for models which are cryopreserved or no longer available as a historical resource.