Nonprofit users may purchase GEM Collection models by signing the appropriate agreement posted on the model page and providing a PO. Depending on the model, the agreement is either the GEM Collection Academic Terms of Sale or a Materials Transfer Agreement.
For models distributed under a Materials Transfer Agreement (only), the key MTA terms are:
Academic customers must provide a scientific workplan within the MTA — answering 4 basic questions:
- Rodent Model Materials are provided only for Research performed by Requestor, not on behalf of a Third Party, and may not be transferred to any Third Party without Merck Sharp & Dohme Corp.'s (MSD) prior written consent.
- A work plan describing the Requestors intended Research scope is required, and, following execution of the Agreement, such work plan may only be changed or expanded through written notice to MSD.
- MSD retains ownership of Rodent Model Materials, including components of such contained in any Modified Derivatives.
- Modified Derivatives may be made and used only by the Requestor in accordance with the Work Plan and terms of the MTA. Modified Derivatives may be transferred to Third Parties only upon amendment of the MTA and establishment of an MTA between such Third Party and MSD.
- The Rodent Model Materials and Modified Derivatives and any information provided may only be used for the Research and may not be used to develop a commercial product. They may only be transferred upon amendment of the MTA and establishment of an MTA between any receiving Third Party and MSD.
- Written report of Research results must be provided to MSD, under terms of confidentiality for MSD's internal use only.
- Inventions and discoveries resulting from the Research must be reported to MSD. MSD may elect to establish a non-exclusive or exclusive license, to be negotiated on reasonable terms.
- MSD has a worldwide, royalty-free, non-exclusive, sublicensable right to use Modified Derivatives.
- No further use of the Rodent Model Materials and Modified Derivatives may be made after the expiration or termination of the MTA.
- For some Rodent Models a Third-Party License may be required.
For what research will the requested mice be used?
Example: To Study the role Histone Deacetylases in cardiac growth under both physiological and pathophysiological conditions, heart failure in particular
How will the mice be used experimentally?
Challenge the hearts of
mice with a global deletion of the HDAC xx gene (KO)
mice that lack HDAC xx gene specifically in cardiomyocytes (cKO)
Cardiac function will be assessed by left ventricular pressure-volume conductance catheterization and transthoracic echocardiography.
What data is expected to be generated and in what timeframe (1 year, 18 months, 2 years, etc.)
Example: Phenotypic data on both Hdac xx KO and cKO in 2 year time frame.
What translational aspects do you envision your data may inform or lead to (better understanding of mechanism, candidate drug targets, better animal model of human disease etc.)?
Example: To dissect the roles of different HDACs for pathological cardiac remodeling and thus the development of heart failure.
A workplan is not needed for models distributed under the Academic Terms of Sale.