Human 22q11.2 Deletion [Df(h22q11)/+] Mouse

Constitutive Knockout (Genomic Deletion)

Human 22q11.2 deletion [Df(h22q11)/+] mouse
This model is impacted by a newly discovered spontaneous mutation in the Thyroglobulin (Tg) gene. It will be removed over time through selective breeding. See the Fact Sheet for more information.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 11026-F
    C57BL/6- Del(16Dgcr2-Hira)1Tac
  • 11026-M
    C57BL/6- Del(16Dgcr2-Hira)1Tac
  • Carries a genomic deletion of a region of mouse chromosome 16 that corresponds to human chromosome region 22q11.2.
  • In humans, hemizygous deletion of chromosome 22q11.2 confers high risk of neurodevelopmental disorders, including autism and schizophrenia, with up to 41% of deletion carriers experiencing psychotic symptoms.
  • Df(h22q11)/+] mice have reduced prepulse inhibition (PPI) and increased acoustic startle response (ASR).
  • Increased NMDAR antagonist-induced locomotion: show increased activity in response to PCP- and ketamine-induced locomotor activity in postpubertal mice.
  • Increased 3,4-Dihydroxyphenylacetic acid (DOPAC) levels in the pre-frontal cortex.
  • Displays phenotype characteristic of narrow palpebral fissures (small eyes).
  • Useful as a model of schizophrenia-like pathology and for studying the underlying biology of schizophrenia and other psychiatric disorders related to 22q11.2 deletion in humans.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.


The Df(h22q11)/+ mouse line was developed for H. Lundbeck A/S, by Taconic Biosciences GmbH (Cologne, Germany), by deletion of the human h22q11.2 orthologous genomic region on mouse chromosome 16. Two targeting vectors were generated using bacterial artificial chromosome clones from the C57BL/6J RPCI-23 library and transfected into TaconicArtemis C57BL/6N Tac embryonic stem cell line. The first vector introduced a loxP site upstream of the Dgcr2 gene. The second vector introduced a loxP site downstream of the Hira gene. Homologous recombinant clones were isolated and the 1.13 megabase region on mouse chromosome 16 between the loxP sites was removed using in vitro Cre-mediated recombination. Hemizygotic embryonic stem cells were injected into blastocysts isolated from impregnated BALB/c female mice and transferred to pseudopregnant NMRI female mice. Chimeric male pups were selected by coat color and mated with wild-type C57BL/6 female mice. Finally, a chimera with germline transmission was selected for expansion breeding.  The colony is maintained by mating wild-type C57BL/6N mice with hemizygous Df(h22q11)/+ mice.


Available off-the shelf





Initial Publication:

Didriksen M, Fejgin K, Nilsson SR, Birknow MR, Grayton HM, Larsen PH, Lauridsen JB, Nielsen V, Celada P, Santana N, Kallunki P, Christensen KV, Werge TM, Stensbøl TB, Egebjerg J, Gastambide F, Artigas F, Bastlund JF, Nielsen J. (2016) Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice. J Psychiatry Neurosci. 2016 Jul 7;41(5):150381.

Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

Welcome! Tell us a little about yourself