Orders by weight:
Contains human cholesteryl ester transfer protein transgene
Exhibits dramatic reduction in serum HDL cholesterol
Useful for identifying and evaluating compounds that increase HDL cholesterol levels and for atherosclerosis studies
Differs from model 1003 in that it has been backcrossed for six additional generations to C57BL/6, thereby reducing genes from the SJL strain
Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background: B6.SJL Background
Origin: The CETP mouse was developed in the laboratory of Dr. David Grass at Xenogen Biosciences, now Taconic. The model was created by microinjecting the human CETP gene into (C57BL/6J x SJL) F2 zygotes. Taconic received stock in April 1996 at the second backcross from the founder line. The mice were then backcrossed one generation to C57BL/6 prior to intercrossing for homozygosity. Backcrossing to C57BL/6NTac recommenced at Taconic in 2004. The line was backcrossed a total of 10 generations (N10) and then intercrossed to homozygosity. A homozygous colony is maintained for the production of hemizygotes through mating to C57BL/6NTac (N11).
Genetics: Wild type for Nnt mutation
Grass, D.S., Saini, U., Felkner, R.H., Wallace, R.E., Lago, W.J.P., Young, S.G., Swanson, M.E. (1995). Transgenic Mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans. The Journal of Lipid Research, Vol. 36, No. 5, pp. 1082-1090