- Expresses high levels of human apolipoprotein B100
- ApoB100 mice show elevated serum levels of LDL cholesterol
- When fed a high fat diet, will develop significant foam cell accumulation underlying the endothelium and within the media, and develop significantly more complex atherosclerotic lesions than control animals
- Useful for identifying and evaluating compounds to reduce elevated levels of LDL cholesterol and the risk of atherosclerosis
- Also useful for studies of lipid transport and atherosclerosis
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background:
C57BL/6 Background
Origin:
The ApoB100 mouse was developed by MacRae F. Linton et. al. of the Gladstone Institute of Cardiovascular Disease. The model was created by microinjecting the human apolipoprotein B100 gene into C57BL/6J x SJL zygotes. The resultant mice were backcrossed to C57BL/6 for 4 generations (N4). Taconic received stock from Xenogen Biosciences in May 1996. The mice are maintained by backcrossing hemizygous ApoB100 mice with C57BL/6NTac inbred mice.
Genetics:
Wild type for Nnt mutation
Color:
Black
Species:
Mouse
Initial Publication:
Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG. (1993).
Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoproteins B100 and Lipoprotein (a).
J Clin Invest, 92: 3029-3037.
