Microbiome and Germ-Free INSIGHTS


The Effect of Gut Bacteria on Bone Health Cannot be Generalized

Previously, a number of different studies using germ-free (GF) mice have indicated that the gut microbiota regulates bone density. However, the results have been conflicting. Reports demonstrate both beneficial and detrimental effects of the microbiota on bone health. A new study published in mSphere in January 2018 positions itself right in between the conflicting previous studies. The researchers demonstrated no effect of different human and murine microbiotas...

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2018 Microbiome Conferences

Looking for a microbiome meeting or conference to attend in 2018? The Translational Microbiome Research Forum (TMRF) lists thirty-two 2018 conferences, so far, and updates their event page upon announcement of new meetings. A quick survey of the events shows eighteen taking place in the US or Canada, twelve in Europe and Israel, and two in Singapore. Twenty-six of these microbiome conferences are general-interest forums, focusing on...

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Microbiome Articles in the Top 5 of Articles Read in 2017

The Translational Scientist Journal announced the top 5 articles of 2017 from their publication. Two of the five articles examine the microbiome; further supporting its stature in life sciences research. Microbiome research continues to be a popular discussion topic for articles, conferences, and in the lay press. One of the microbiome focused articles is Exploring the Microbiome — with Mice. Taconic Biosciences' Director of Microbiome Products and...

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Does Roundup® Residue on Food Impact your Microbiome?

The herbicide glyphosate (Roundup® and other tradenames) works by inhibiting synthesis of aromatic amino acids in the shikimate pathway, which is active in plants as well as bacteria, but not in mammalian species. Thus while glyphosate cannot adversely affect humans via its primary mode of action, the possibility that it could affect the bacteria of the human microbiome exists. Researchers from the Technical University of Denmark and...

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Gut Microbiome and the Efficacy of Cancer Immunotherapy

Two new studies in humans published in Science in November 2017 support previous findings in mice: that response to cancer therapy is dependent on the gut microbiome1,2. This opens the possibility for researchers to explore deliberate exploitation of the microbiome in improving the efficacy of cancer therapy. While checkpoint inhibitors have been a great leap forward in the treatment of certain cancer types, only a limited portion...

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Webinar Review: How to Harness the Microbiome

Rodent model microbiomes introduce confounding effects in an alarming range of study endpoints. In a recent webinar, Aaron Ericsson, Research Assistant Professor and Director of Metagenomics at the University of Missouri, reviewed emerging best practices to identify and control for relevant microbiota, improving the accuracy and reproducibility of your preclinical research. Dr. Ericsson discussed topics ranging from how the microbiome contributes to experimental variability and reproducibility to...

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How Does the Microbiome Affect Your Mouse Model?

Lactobacillus reuterii Induces Gut Intraepithelial CD4+CD8αα+ T Cells Researchers are still determining the full effect of the gut microbiota on immune system development. The best known example being reliance of Th17 responses on the presence of segmented filamentous bacteria (SFB). This past August, researchers at Washington University published a paper titled, "Lactobacillus reuterii induces gut intraepithelial CD4+CD8αα+ T cells" in the journal, Science. The authors demonstrated another...

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Hot Topics at AALAS National Meeting 2017

During the week of October 15, 2017, I attended the 68th National AALAS meeting in Austin, Texas. It has been almost twenty years since I attended my first AALAS National meeting, and it was an excellent opportunity to meet new people and reconnect with colleagues to share lab animal science news. The meeting had ten posters and six platform sessions related to the animal model microbiome. Julia...

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Foundational Gnotobiotics Concepts

Gnotobiology isn't new, but the dramatic expansion of microbiome research has outpaced the development of a common nomenclature within the gnotobiotic research community. Many different, and sometimes confusing, terms are used when referring to different gnotobiotic concepts. To help, here's an overview of the most commonly used gnotobiotic rodent model concepts with examples of how these concepts are applied in basic research and drug discovery. Gnotobiology means...

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Microbiome Summit Exploring Industry-Academic Partnerships

International microbiome experts from academia and industry recently came together for the inaugural Microbiome Summit in Copenhagen, Denmark on October 5, 2017. Hosted by the Medicon Valley Alliance (MVA), this summit was intended to "bring together key ... stakeholders from academia, industry and the hospital sector ... to develop knowledge-sharing and a strong scientific community," according to chairman Morten Sommer. Sommer, also a Professor at the Novo...

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