Microbiome and Germ-Free INSIGHTS

Webinar Q&A — Microbiological Monitoring of Germ-Free and Gnotobiotic Colonies

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Dr. Paula Roesch recently presented a webinar on microbiological monitoring of germ-free and gnotobiotic colonies. Taconic Biosciences has decades of experience in this area and Dr. Roesch presented a thorough look at all aspects of the process, starting from tools and approaches to process validation and monitoring and moving into isolator monitoring techniques. She even included lessons learned from a case study where things didn't go as...  Read More

2020 Microbiome Conferences

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Please see the Translational Microbiome Research Forum's Events for updated information regarding meeting cancellations and changes Looking for a microbiome conference or workshop? 2020 looks to be a banner year for microbiome conferences. Here are some upcoming sessions we'll be following with interest. 2020 Microbiome Conferences The Translational Microbiome Research Forum (TMRF) is still among the best options for finding microbiome-related events and workshops. They list over...  Read More

Webinar Q&A — Controlling the Macroenvironment: A Novel Approach to Germ-free Derivations

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Dr. Cristina Weiner recently presented a webinar featuring a novel approach to germ-free derivations. She discussed the importance of understanding baseline performance and making incremental process improvements as well as how Taconic Biosciences developed and implemented a new facility design which supports improved germ-free derivation success. We present the full webinar Q&A here. Dr. Cristina Weiner: While recognizing that the germ-free integrity of the animal is most...  Read More

Genetic Background of Mice Influences Microbiome

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Source: Graphical Abstract. Khan et al., 20191 The microbiome continues to be an important topic in both human health research and in popular culture. The microbiome is cited as a factor in multiple diseases, neurological conditions, and immune responses to foreign pathogens. Specific compositions of gut commensal bacteria have been associated with an increased incidence of depression, varying responses to immunotherapies, and the progression of neurodegenerative disease...  Read More

Microbe Helps Hosts Exercise Longer

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A recent study published in Nature Medicine reports on the correlation between rigorous exercise and the increase in abundance of a specific bacterial genus in the human gut microbiome. The collaborative group, which includes CRISPR-researcher George Church from Harvard Medical School, established a connection between the abundance of Veillonella atypica and an increased ability to tolerate fitness1. This article adds to the growing evidence that the microbiome...  Read More

The Next Ten Years of Microbiome Research

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Source: Proctor1 The Human Microbiome Project's former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature1. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has consumed more than $1.7B (USD). More than $1B has come...  Read More

FDA Issues Safety Alert on Investigational Use of Fecal Microbiota Transplantation

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Fecal microbiota transplantation (FMT) is the transfer of fecal matter from a healthy individual into a recipient with the goal of treating an ailment. In its simplest form FMT has been used to treat disease with reports detailing its use as far back as 1700 years ago in China1. Modern applications of this procedure have been developed to treat Clostridium difficile infections, colitis, and irritable bowel syndrome...  Read More

World Microbiome Day 2019

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World Microbiome Day is on June 27th this year. World Microbiome Day began in 2018 to demonstrate its emergence as a subject with global impact. That impact is being felt across a variety of disciplines including science, medicine, and nutrition. "World Microbiome Day aims to showcase the vibrant and diverse worlds of microbiomes, and to encourage public dialogue on their critical importance to human, animal and environmental...  Read More

Transportation Affects Gut Microbiome of Laboratory Mice

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Experimental controls are at the center of every quality experiment, and understanding the causes of microbiome variability is key to controlling for microbiome-related effects. Researchers that utilize murine models attempt to control for possible microbiome variability by ordering mice from the same vendor, using littermate controls, and employing co-housing strategies1. Given the ongoing research reproducibility crisis, it is vital to understand potential factors that contribute to microbiome...  Read More

How Antibiotics Affect Your Microbiome

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The human gut microbiome is a complex, highly-evolved commensal community with an integral role in your response to disease and how well you maintain homeostasis. While commensal bacteria vary from person to person, a person's specific microbiome should contain the same relative percentage of bacterial species over their lifespan. The balance of this community can be altered for weeks, months, and even years depending on diet, environmental...  Read More