Microbiome and Germ-Free INSIGHTS


2017 Microbiome in Mouse Models Workshop Review — Best Practices

Part III: Best Practices for Study Design This is the third of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design In this Insight, we will summarize the main findings of workshop...

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2017 Microbiome in Mouse Models Workshop Review — Key Topics

Part II: Microbiome Workshop Topics This is the second of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design In this Insight, we recap workshop topics and discussions relating to the use...

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2017 Microbiome in Mouse Models Workshop Review

Part I: Participants and Presentations This is the first of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design Participating Scientists The microbiome workshop was led by Alexander Maue, PhD, director of...

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HIV Drug Efficacy Affected by Microbiome Composition

The metabolism of pharmacological compounds by our inhabitant microbes can have a significant effect on drug efficacy. While the best-known example may be the inactivation of the drug digoxin by gut flora1, Klatt et al. recently demonstrated that an imbalance in the healthy vaginal microbiome impacts the efficacy of a human immunodeficiency virus (HIV) drug2. Efficacy of Tenofovir Gel Affected by Vaginal Microbiome Composition Tenofovir is a...

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Can Anxiety Phenotypes Transfer via FMT?

Connections between behavioral phenotypes and the microbiome continue to emerge from fecal microbiota transplantation (FMT) studies at McMaster University. Can Behavioral Phenotypes Be Transferred? Researchers at McMaster University first demonstrated the transfer of behavioral traits between mice via the gut microbiome by fecal microbiota transplantation (FMT) in 2011. The authors exploited the observation that two strains of mice, inbred BALB/c and outbred NIH Swiss mice with differing...

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Murine Lung Microbiome Webinar Recap

On June 8, Dr. Kenneth Klingenberg Barfod — of the National Research Centre for the Working Environment, Denmark — presented a webinar on the importance of the murine lung microbiome, how the lung microbiome in mice can be manipulated experimentally, and its applications in disease modeling. Compared to the extensively studied gut microbiome, the lung microbiome is a niche research area with relatively few published reports. A...

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The Medicinal Microbiome: Presentations of Note

A growing number of scientists are investigating the role of our microbiome in the development of and protection from disease. One area of particular interest is recovery from injury and infection. Recent publications examine the relationship between the microbiome and HIV infection (Wei Yang JS, 2017), harnessing microbiome targeted therapies to reduce post-operative complications (Kasatpibal N, 2017), and the impact of environmental toxins on increasing antimicrobial resistant...

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Industrial PhD Program Supports Microbiota Research

Three years ago, Taconic Biosciences and the University of Copenhagen came together to sponsor an Industrial PhD student through a program supported by Innovation Fund Denmark (IFD). IFD invests in new knowledge and technology creating growth and employment in Denmark. The Industrial PhD Program The Industrial PhD program provides opportunities to students that might not otherwise be available in a traditional PhD program. Applicants accepted into the...

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The Microbiome and Visceral Pain

The gut microbiome may contribute to or modulate the pain of visceral hypersensitivity, but how the microbiome affects neurotransmission, pain perception, and GI function is not well understood. Pokusaeva and colleagues hypothesized that production of the neurotransmitter γ-aminobutyric acid (GABA) by gut bacteria such as Lactobacillus and Bifidobacterium might be one mechanism through which the microbiome-gut-brain axis functions to modulate visceral pain. Connecting the Microbiome and Visceral...

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What Are Germ-Free Mice and How Are They Sourced?

Understanding what germ-free mice are, the opportunities that they offer, and how you can obtain them will help you decide how best to incorporate these models into your research program. The body is inhabited by trillions of microorganisms (the microbiome, consisting of bacteria, fungi, viruses, etc.) which play major roles in health and disease. Axenic or germ-free mice, specially-raised animals devoid of all microorganisms, are increasingly powerful...

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