Microbiome and Germ-Free INSIGHTS


Diets High in Salt May Increase Sensitivity to Autoimmune Disease through Microbiome Alteration

High salt diets have previously been shown to increase severity of certain types of induced autoimmune disease in mouse models via a signaling pathway, but the impact of these diets on the gut microbiome and intestinal inflammation have not been studied. Researchers at McMaster University recently investigated this question in a paper titled "High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production"...

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New Resource for Gnotobiotics Research

Growth in Gnotobiotics Research in gnotobiotic rodents and other animal models is a growing field. The rise in microbiome studies is likely responsible for this increase. This gnotobiotic renaissance has fueled exponential growth in the number of institutions operating or making plans for gnotobiotic facilities and a demand for more education. The non-profit organization, the Association for Gnotobiotics, is answering this need for gnotobiotic knowledge by publishing...

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Commensal Microbes May Initiate and Drive Immune Responses in Lupus

Spontaneous lupus erythematosus (SLE) is a chronic autoimmune disease with an unclear cause. Nearly all lupus patients have high levels of anti-nuclear antibodies with a relatively high proportion being pathogenic anti-Ro protein antibodies. At the end of March, researchers at Yale University published a paper entitled "Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus" in the journal Science Translational Medicine in which...

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Non-Antibiotic Drugs Impact the Human Gut Microbiota

A new study in Nature, published in March 2018, revealed novel potential adverse effects of a broad variety of marketed drugs. The researchers found that many drugs designed to target human cells and not microbes could inhibit the growth of different intestinal bacterial strains. This suggests that these drugs can alter the gut microbiota, in turn leading to adverse effects on human health. The study was an...

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Gender-Dependent Impacts of Herbicides on the Microbiome

It is heavily debated whether the use of the weedkiller glyphosate in agriculture and gardening can induce dysbiosis of the gut microbiota, negatively affecting human and animal health. Dysbiosis is an imbalance in the microbiome composition associated with conditions such as colitis, metabolic syndrome, allergies, and more. Herbicides and the Microbiome We recently highlighted new Danish research showing that pure glyphosate and commercial formulations of glyphosate (e.g....

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Microbiome Cycles Revealed by Low-Cost Gnotobiotic Cages

While developing a low-cost alternative to traditional gnotobiotic isolators, a team of researchers at Case Western Reserve University (CWRU) were able to characterize cyclical changes in the microbiomes of gnotobiotic mice. Their research has implications for both the design and affordability of gnotobiotic animal model research. High Cost of Gnotobiotic Isolators Isolators are the gold standard for rearing germ-free mice, but it is sometimes difficult to justify...

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Mice with Horse Microbiota Validate Health Promoting Diet for Foals

Photo courtesy of F. Lindenberg Animal feed retailer Brogaarden recently launched a new prebiotic diet for foals that can reduce the risk of developing conditions such as Equine Metabolic Syndrome and colitis later in life. The diet works by promoting beneficial gut bacteria, such as Akkermansia muciniphila, in turn inducing regulatory immunity in the foals. The diet's effects were scientifically demonstrated by Industrial PhD Student Frederikke Lindenberg,...

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The Effect of Gut Bacteria on Bone Health Cannot be Generalized

Previously, a number of different studies using germ-free (GF) mice have indicated that the gut microbiota regulates bone density. However, the results have been conflicting. Reports demonstrate both beneficial and detrimental effects of the microbiota on bone health. A new study published in mSphere in January 2018 positions itself right in between the conflicting previous studies. The researchers demonstrated no effect of different human and murine microbiotas...

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2018 Microbiome Conferences

Looking for a microbiome meeting or conference to attend in 2018? The Translational Microbiome Research Forum (TMRF) lists thirty-two 2018 conferences, so far, and updates their event page upon announcement of new meetings. A quick survey of the events shows eighteen taking place in the US or Canada, twelve in Europe and Israel, and two in Singapore. Twenty-six of these microbiome conferences are general-interest forums, focusing on...

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Microbiome Articles in the Top 5 of Articles Read in 2017

The Translational Scientist Journal announced the top 5 articles of 2017 from their publication. Two of the five articles examine the microbiome; further supporting its stature in life sciences research. Microbiome research continues to be a popular discussion topic for articles, conferences, and in the lay press. One of the microbiome focused articles is Exploring the Microbiome — with Mice. Taconic Biosciences' Director of Microbiome Products and...

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