Colony Management Solutions INSIGHTS

Methods of Animal Model Identification

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Animal identification is a vital element in any research project requiring the use of animal models. The identification of an animal may be the only link to essential data, such as sex, genotype, study parameters, and results. Animal identification systems also assist with breeding record keeping. In some cases, the success of your studies may depend on the type of animal identification method you choose. Accuracy of...  Read More

Acclimating Rodents to Automated Watering

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If your animal models fail to learn and use their new watering system, dehydration and death may follow. How can you help them adjust? Learning to Use Automated Watering Systems Several rodent suppliers prefer water bottles for their watering systems. The advantage of the water bottle is the sipper tube always has a drop of water on the tip, easily located by young rats and mice. When...  Read More

Rpe65 Variants Affect Vision in Animal Models

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Vision researchers are very familiar with several mutations which can affect sight in mice. Chang et al. cataloged 16 separate mutations causing retinal degeneration. Two of the better known mutations are Pde6brd1 (commonly called rd1) and Crb1rd8 (commonly called rd8). The rd1 mutation is present in a number of inbred strains, such as FVB and SJL, and causes blindness by weaning age. The rd8 mutation is present...  Read More

Should You Breed or Buy Your Own Rodent Models?

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Many research investigators are faced with a decision: should they buy laboratory rodents from a commercial vendor, or produce them with an in-house breeding colony? There are many factors to evaluate before the decision to "breed or buy" can be made. Following are a few questions and considerations that must be addressed before an informed decision can be made: Are the rodents available from a commercial vendor?...  Read More

"Collaborative Research Organizations" Are Your New CRO

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Over the last two decades, the pharmaceutical industry has faced increasing challenges: declining R&D productivity, rising costs, competition from generics, greater regulatory complexity, and changing expectations of patient-centered healthcare. In response to these pressures, many companies are transforming the way in which medicines are discovered, developed, and brought to market. Two key trends are emerging: The proliferation of digital biotechs The externalization of drug development Contract Research...  Read More

Cryopreservation in Colony Management

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Use of genetically engineered rodent models in research requires the lines to be maintained in continuous breeding, which is costly, labor intensive, and takes up limited vivarium space. Also when such colonies are the sole source of the model, there is risk of losing the line altogether to unanticipated death, disease, infertility, genetic drift, or microbial contamination. Effective use of cryopreservation allows researchers to better utilize financial...  Read More

A Successful Breeding Plan in Five Steps

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"It's just breeding... right?" You may want to carry out large cohort studies within the next 4-6 months, or to quickly recover a cryopreserved line from your collaborator to cross with your own knockout line. How difficult can it be? The temptation of getting there fast may make you plunge into a new project right away. But early missteps in colony management can surface months into a...  Read More

Easier Said than Bred: 4 Considerations for Breeding Laboratory Mice

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Have you ever had a mouse infestation in your house? This is a pesky problem that can prove difficult to resolve. After all, they breed like... well, mice. So why is it so difficult to breed laboratory mice? Laboratory mice are purpose-bred for specific phenotypes or traits, not to optimize litter size. Quite often, fecundity is sacrificed to attain traits desired for laboratory mouse studies, or breeding...  Read More

Academic Research - Pool of available GEMs increases by 75 models

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Taconic Biosciences has recently added an additional 75 mouse models to the GEM Collection Repository. The GEM Collection's nearly 300 lines provide academic and nonprofit researchers worldwide with unparalleled access to a wide range of genetically engineered mouse models. These mouse models are relevant to several disease areas, such as cardiovascular, diabetes/ endocrinology, neuroscience, oncology, respiratory, and immunology. The GEM Collection repository offers nonprofit researchers immediate access...  Read More

Additional Mouse Models Added to the Knockout Repository

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Taconic Biosciences has recently added an additional 19 mouse models to the Knockout Repository (KOR). The KOR's more than 4,100 lines provide academic and commercial researchers worldwide with unparalleled access to fully licensed knockout mouse models. This repository offers the scientific community immediate access to expertly designed, highly valuable research tools that rapidly accelerate translational research and the drug discovery and development processes. Mutations are focused on...  Read More