
NASH models based on the Amylin liver NASH (AMLN) model use male C57BL/6 mice conditioned on diet for between 18-40 weeks or even longer, resulting in obese mice which may be prone to aggression and specific health concerns. Some of the factors to consider when bringing these models into your vivarium are enrichment, housing groups, and visual monitoring for skin conditions. Most laboratory mice lose some weight during transit; however, for NASH models, this results in disease regression and acclimation times must be based on weight recovery. If not properly acclimated, this could impact downstream study results. Taconic's new NASH care guide covers these issues and makes detailed recommendations to preserve the health and welfare of these mice. If you require additional information about introducing NASH models to your facility or proper study design, we offer scientific consultations to help you navigate this process.

- Contact Us to set up a free consultation with a Taconic scientist on how you can use NASH in your research.