hIL-2 NOG Publications

hIL-2 NOG Model Page

Filter publications by application: All Antibody-Dependent-Cellular Cytotoxicity (ADCC) Autoimmune Colon Cancer Gene/Cell therapy Humanized Immuno-Oncology Immunology Immunotherapy Leukemia Lung Cancer Melanoma NK Oncology Patient Derived Xenograft (PDX) T And/Or B Cell Function Transplantation Research And Graft Versus Host Disease (GVHD)
Filter publications by model type: All Humanization Random integration transgene



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Schmidt J, et al.
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Schmidt J, Chiffelle J, Perez MAS, Magnin M, Bobisse S, Arnaud M, Genolet R, Cesbron J, Barras D, Navarro Rodrigo B, Benedetti F, Michel A, Queiroz L, Baumgaertner P, Guillaume P, Hebeisen M, Michielin O, Nguyen-Ngoc T, Huber F, Irving M, Tissot-Renaud S, Stevenson BJ, Rusakiewicz S, Dangaj Laniti D, Bassani-Sternberg M, Rufer N, Gfeller D, Kandalaft LE, Speiser DE, Zoete V, Coukos G, Harari A
(2023) Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors. Nat Commun 14(1):3188
T And/Or B Cell Function, Oncology, Colon Cancer, Immunotherapy, Lung Cancer, Melanoma, Immuno-Oncology
Hall MS, et al.
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Hall MS, Mullinax JE, Cox CA, Hall AM, Beatty MS, Blauvelt J, Innamarato P, Nagle L, Branthoover H, Wiener D, Schachner B, Martinez AJ, Richards AD, Rich CJ, Col�n Col�n M, Schell MJ, Teer JK, Khushalani NI, Weber JS, Mul� JJ, Sondak VK, Pilon-Thomas S, Sarnaik AA.
(2022) Combination Nivolumab, CD137 Agonism, and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma Clin Cancer Res. 2022 Dec 15;28(24):5317-5329.
T And/Or B Cell Function, Oncology, Immunotherapy, Melanoma, Patient Derived Xenograft (PDX), Immuno-Oncology, Gene/Cell therapy
Christensen PKF, et al.
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Christensen PKF, Hansen AK, Skov S, Engkilde K, Larsen J, H�yer-Hansen MH, Koch J.
(2023) Sustaining the T-cell activity in xenografted psoriasis skin PLoS One. 2023 Jan 17;18(1):e0278390.
Autoimmune, T And/Or B Cell Function
Eliana Ruggiero, et al.
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Eliana Ruggiero, Dai Liu, Aaron Prodeus, Amy M Becker, Maxwell Foisey, Ishina Balwani, Ivy Dutta, Qingzhan Zhang, Simo M Arredouani, Mark McKee, Fabio Ciceri, Laura Sepp-Lorenzino, Chiara Bonini, Birgit C Schultes
(2021) NTLA5001, a T Cell Product Candidate with CRISPR-Based Targeted Insertion of a High-Avidity, Natural, WT1-Specific TCR, Shows Efficacy in In Vivo Models of AML and ALL ASH 2021 presentation
T And/Or B Cell Function, Oncology, Immunotherapy, Leukemia, Immuno-Oncology, Gene/Cell therapy
Forsberg EMV, et al.
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Forsberg EMV, Riise R, Saellstr�m S, Karlsson J, Als�n S, Bucher V, Hemminki AE, Olofsson Bagge R, Ny L, Nilsson LM, R�nnberg H, Nilsson JA.
(2023) Treatment with Anti-HER2 Chimeric Antigen Receptor Tumor-Infiltrating Lymphocytes (CAR-TILs) Is Safe and Associated with Antitumor Efficacy in Mice and Companion Dogs Cancers 2023, 15(3), 648
Immunotherapy, Melanoma, Immuno-Oncology, Gene/Cell therapy
Liang F, et al.
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Liang F, Nilsson LM, Byvald F, Rezapour A, Taflin H, Nilsson JA, Yrlid U
(2022) A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells. Cancers (Basel) 14(12)
Hofving T, et al.
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Hofving T, Liang F, Karlsson J, Yrlid U, Nilsson JA, Nilsson O, Nilsson LM
(2021) The Microenvironment of Small Intestinal Neuroendocrine Tumours Contains Lymphocytes Capable of Recognition and Activation after Expansion. Cancers (Basel) 13(17)
Oncology, Immuno-Oncology
Tatiana V. Kudling, et al.
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Tatiana V. Kudling, James H.A. Clubb, Dafne C.A. Quixabeira, Joao M. Santos, Riikka Havunen, Alexander Kononov, Camilla Heini�, Victor Cervera-Carrascon, Santeri Pakola, Saru Basnet, Susanna Gr�nberg-V�h�-Koskela, Victor Arias, Ivan Gladwyn-Ng, Katri Aro, Leif B�ck, Jari R�s�nen, Ilkka Ilonen, Kristian Borenius, Mikko R�s�nen, Otto Hemminki, Antti Rannikko, Anna Kanerva, Johanna Tapper, Akseli Hemminki
(2022) Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression OncoImmunology, 11:1, DOI: 10.1080/2162402X.2022.2096572
Oncology, Patient Derived Xenograft (PDX), Immuno-Oncology
Arnaud M, et al.
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Arnaud M, Chiffelle J, Genolet R, Navarro Rodrigo B, Perez MAS, Huber F, Magnin M, Nguyen-Ngoc T, Guillaume P, Baumgaertner P, Chong C, Stevenson BJ, Gfeller D, Irving M, Speiser DE, Schmidt J, Zoete V, Kandalaft LE, Bassani-Sternberg M, Bobisse S, Coukos G, Harari A
(2022) Sensitive identification of neoantigens and cognate TCRs in human solid tumors. Nat Biotechnol
Muralidharan SV, et al.
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Muralidharan SV, Nilsson LM, Lindberg MF, Nilsson JA
(2020) Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells. Life Sci Alliance 3(8)
�?nar �, et al.
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�?nar �, Brzezicha B, Grunert C, Kloetzel PM, Beier C, Peuker CA, Keller U, Pezzutto A, Busse A
(2021) High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies. J Immunother Cancer 9(7)
Ny L, et al.
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Ny L, Rizzo LY, Belgrano V, Karlsson J, Jespersen H, Carstam L, Bagge RO, Nilsson LM, Nilsson JA
(2020) Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse models. Ann Oncol 31(2):266-273
Helleday T
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Helleday T
(2020) Using personalized immune-humanized xenograft mouse models to predict immune checkpoint responses in malignant melanoma: potential and hurdles. Ann. Oncol. 31(2):167-168
Forsberg EM, et al.
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Forsberg EM, Lindberg MF, Jespersen H, Als�n S, Olofsson Bagge R, Donia M, Svane IM, Nilsson O, Ny L, Nilsson LM, Nilsson JA
(2019) HER2 CAR-T cells eradicate uveal melanoma and T cell therapy-resistant human melanoma in interleukin-2 (IL-2) transgenic NOD/SCID IL-2 receptor knockout mice. Cancer Res.
Einarsdottir BO, et al.
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Einarsdottir BO, Karlsson J, S�derberg EMV, Lindberg MF, Funck-Brentano E, Jespersen H, Brynjolfsson SF, Bagge RO, Carstam L, Scobie M, Koolmeister T, Wallner O, Stierner U, Berglund UW, Ny L, Nilsson LM, Larsson E, Helleday T, Nilsson JA
(2018) A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. Cell Death Dis 9(8):810
Humanization, Random integration transgene
T And/Or B Cell Function, Oncology, Melanoma, Humanized
Paul Volden, et al.
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Paul Volden, Azusa Tanaka, Dimitri Gimnopoulos, Magdalena Paterka, Iduna Fichtner
(2018) Cytokine-transgenic NOG mice engrafted with human peripheral blood cells support natural killer cell expansion � American Association for Cancer Research 2018 Conference
Humanization, Random integration transgene
Immunology, NK, Antibody-Dependent-Cellular Cytotoxicity (ADCC), Transplantation Research And Graft Versus Host Disease (GVHD), Immunotherapy, Immuno-Oncology, Gene/Cell therapy
Jespersen H, et al.
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Jespersen H, Lindberg MF, Donia M, S�derberg EMV, Andersen R, Keller U, Ny L, Svane IM, Nilsson LM, Nilsson JA
(2017) Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model. Nat Commun 8(1):707
Immunology, Oncology, Humanized
Ito R, et al.
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Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M
(2016) A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice. Am. J. Transplant.
Katano I, et al.
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Katano I, Takahashi T, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M
(2015) Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse. J. Immunol. 194(7):3513-25

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