hIL-2 NOG Publications

hIL-2 NOG Model Page

Filter publications by application: All Antibody-Dependent-Cellular Cytotoxicity (ADCC) Gene/Cell therapy Humanized Immuno-Oncology Immunology Immunotherapy Melanoma NK Oncology T And/Or B Cell Function Transplantation Research And Graft Versus Host Disease (GVHD)
Filter publications by model type: All Humanization Random integration transgene



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Muralidharan SV, et al.
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Muralidharan SV, Nilsson LM, Lindberg MF, Nilsson JA
(2020) Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells. Life Sci Alliance 3(8)
Çınar Ö, et al.
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Çınar Ö, Brzezicha B, Grunert C, Kloetzel PM, Beier C, Peuker CA, Keller U, Pezzutto A, Busse A
(2021) High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies. J Immunother Cancer 9(7)
Ny L, et al.
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Ny L, Rizzo LY, Belgrano V, Karlsson J, Jespersen H, Carstam L, Bagge RO, Nilsson LM, Nilsson JA
(2020) Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse models. Ann Oncol 31(2):266-273
Helleday T
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Helleday T
(2020) Using personalized immune-humanized xenograft mouse models to predict immune checkpoint responses in malignant melanoma: potential and hurdles. Ann. Oncol. 31(2):167-168
Forsberg EM, et al.
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Forsberg EM, Lindberg MF, Jespersen H, Alsén S, Olofsson Bagge R, Donia M, Svane IM, Nilsson O, Ny L, Nilsson LM, Nilsson JA
(2019) HER2 CAR-T cells eradicate uveal melanoma and T cell therapy-resistant human melanoma in interleukin-2 (IL-2) transgenic NOD/SCID IL-2 receptor knockout mice. Cancer Res.
Einarsdottir BO, et al.
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Einarsdottir BO, Karlsson J, Söderberg EMV, Lindberg MF, Funck-Brentano E, Jespersen H, Brynjolfsson SF, Bagge RO, Carstam L, Scobie M, Koolmeister T, Wallner O, Stierner U, Berglund UW, Ny L, Nilsson LM, Larsson E, Helleday T, Nilsson JA
(2018) A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. Cell Death Dis 9(8):810
Humanization, Random integration transgene
T And/Or B Cell Function, Oncology, Melanoma, Humanized
Paul Volden, et al.
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Paul Volden, Azusa Tanaka, Dimitri Gimnopoulos, Magdalena Paterka, Iduna Fichtner
(2018) Cytokine-transgenic NOG mice engrafted with human peripheral blood cells support natural killer cell expansion   American Association for Cancer Research 2018 Conference
Humanization, Random integration transgene
Immunology, NK, Antibody-Dependent-Cellular Cytotoxicity (ADCC), Transplantation Research And Graft Versus Host Disease (GVHD), Immunotherapy, Immuno-Oncology, Gene/Cell therapy
Jespersen H, et al.
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Jespersen H, Lindberg MF, Donia M, Söderberg EMV, Andersen R, Keller U, Ny L, Svane IM, Nilsson LM, Nilsson JA
(2017) Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model. Nat Commun 8(1):707
Immunology, Oncology, Humanized
Ito R, et al.
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Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M
(2016) A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice. Am. J. Transplant.
Katano I, et al.
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Katano I, Takahashi T, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M
(2015) Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse. J. Immunol. 194(7):3513-25

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