Diet Induced Obese (DIO) B6 Publications

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Holst B, et al.
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Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye D, Qvortrup K, Huganir R, Stamou D, Kjærulff O, Gether U
(2013) PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol. 11(4):e1001542
Camacho S, et al.
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Camacho S, Michlig S, de Senarclens-Bezençon C, Meylan J, Meystre J, Pezzoli M, Markram H, le Coutre J
(2015) Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Sci Rep 5:7919
Penke M, et al.
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Penke M, Larsen PS, Schuster S, Dall M, Jensen BA, Gorski T, Meusel A, Richter S, Vienberg SG, Treebak JT, Kiess W, Garten A
(2015) Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet. Mol. Cell. Endocrinol. 412:65-72
Chen Y, et al.
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Chen Y, Song M, Riley JP, Hu CC, Peng X, Scheuner D, Bokvist K, Maiti P, Kahl SD, Montrose-Rafizadeh C, Hamdouchi C, Miller AR
(2016) A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes. Pharmacol Res Perspect 4(6):e00278
Diabetes (Type 2)
Shin Wen, et al.
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Shin Wen, Kavita S. Jadhav, David L. Williamson, Todd C. Rideout
(2013) Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice Journal of lipids
L.M. Vaanholt, et al.
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L.M. Vaanholt, R.E. Sinclair, S.E. Mitchell and J.R. Speakman
(2015) Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice Physiology & Behavior Volume 144, 15 May 2015, Pages 146–155
Fontaine DA, et al.
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Fontaine DA, Davis DB
(2016) Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33
Montgomery MK, et al.
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Montgomery MK, Hallahan NL, Brown SH, Liu M, Mitchell TW, Cooney GJ, Turner N
(2013) Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 56(5):1129-39
Pettersson US, et al.
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Pettersson US, Waldén TB, Carlsson PO, Jansson L, Phillipson M
(2012) Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue. PLoS ONE 7(9):e46057
Vickers SP, et al.
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Vickers SP, Jackson HC, Cheetham SC
(2011) The utility of animal models to evaluate novel anti-obesity agents. Br. J. Pharmacol. 164(4):1248-62
Hariri N, et al.
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Hariri N, Thibault L
(2010) High-fat diet-induced obesity in animal models. Nutr Res Rev 23(2):270-99
Bradley RL, et al.
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Bradley RL, Jeon JY, Liu FF, Maratos-Flier E
(2008) Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am. J. Physiol. Endocrinol. Metab. 295(3):E586-94
Anderson SR, et al.
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Anderson SR, Gilge DA, Steiber AL, Previs SF
(2008) Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice. Metab. Clin. Exp. 57(3):347-54
Buettner R, et al.
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Buettner R, Schölmerich J, Bollheimer LC
(2007) High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15(4):798-808
Sumiyoshi M, et al.
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Sumiyoshi M, Sakanaka M, Kimura Y
(2006) Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice. J. Nutr. 136(3):582-7
Hambly C, et al.
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Hambly C, Adams A, Fustin JM, Rance KA, Bünger L, Speakman JR
(2005) Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet. Obes. Res. 13(3):556-66
Metabolic Syndrome
Hu CC, et al.
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Hu CC, Qing K, Chen Y
(2004) Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice. Obes. Res. 12(8):1264-70
Wei P, et al.
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Wei P, Lane PH, Lane JT, Padanilam BJ, Sansom SC
(2004) Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes. Diabetologia 47(9):1541-9
Diabetes (Type 2)
Xu H, et al.
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Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H
(2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112(12):1821-30
Inflammation
Harris RB, et al.
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Harris RB, Bowen HM, Mitchell TD
(2003) Leptin resistance in mice is determined by gender and duration of exposure to high-fat diet. Physiol. Behav. 78(4-5):543-55
Steppan CM, et al.
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Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA
(2001) The hormone resistin links obesity to diabetes. Nature 409(6818):307-12
M Van Heek, et al.
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M Van Heek, D S Compton, C F France, R P Tedesco, A B Fawzi, M P Graziano, E J Sybertz, C D Strader, and H R Davis, Jr
(1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 1997 Feb 1; 99(3): 385–390
Steven P Vickers, et al.
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Steven P Vickers, Helen C Jackson, and Sharon C Cheetham
(2011) The utility of animal models to evaluate novel anti-obesity agents Br J Pharmacol. 2011 Oct; 164(4): 1248–1262
Jina Hong, et al.
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Jina Hong, Renee E Stubbins, Rebekah R Smith, Alison E Harvey, and Nomelí P Núñez
(2009) Differential susceptibility to obesity between male, female and ovariectomized female mice Nutr J. 2009; 8: 11
Alesia Walker, et al.
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Alesia Walker, Barbara Pfitzner, Susanne Neschen, Melanie Kahle, Mourad Harir, Marianna Lucio, Franco Moritz, Dimitrios Tziotis, Michael Witting, Michael Rothballer, Marion Engel, Michael Schmid, David Endesfelder, Martin Klingenspor, Thomas Rattei, Wolfgang zu Castell, Martin Hrabé de Angelis, Anton Hartmann and Philippe Schmitt-Kopplin
(2014) Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet The ISME Journal (2014) 8, 2380–2396
Angela M. Gajda, et al.
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Angela M. Gajda, MS, Michael A. Pellizzon, Ph.D., Matthew R. Ricci, Ph.D. and Edward A. Ulman
(2007) Diet-Induced Metabolic Syndrome in Rodent Models Animal Lab News
Rajpal DK, et al.
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Rajpal DK, Klein JL, Mayhew D, Boucheron J, Spivak AT, Kumar V, Ingraham K, Paulik M, Chen L, Van Horn S, Thomas E, Sathe G, Livi GP, Holmes DJ, Brown JR
(2015) Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models. PLoS ONE 10(12):e0145499
Diabetes (Type 1), Infectious Disease, Microbiome, Diabetes (Type 2)
Campbell SC, et al.
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Campbell SC, Wisniewski PJ, Noji M, McGuinness LR, Häggblom MM, Lightfoot SA, Joseph LB, Kerkhof LJ
(2016) The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice. PLoS ONE 11(3):e0150502
Infectious Disease, Microbiome
Almind K, et al.
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Almind K, Kahn CR
(2004) Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53(12):3274-85
Cardiovascular, Metabolism