Diet Induced Obese (DIO) B6 Publications

Diet Induced Obese (DIO) B6 Model Page

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Tomaszewski MR, et al.
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Tomaszewski MR, Meng X, Haley HD, Harrell CM, Mcdonald TP, Miller CO, Smith SM
(2023) Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment. J Lipid Res 64(8):100408
Neuroscience, Metabolic Syndrome
Urva S, et al.
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Urva S, Coskun T, Loghin C, Cui X, Beebe E, O'Farrell L, Briere DA, Benson C, Nauck MA, Haupt A
(2020) The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists. Diabetes Obes Metab 22(10):1886-1891
Quante M, et al.
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Quante M, Iske J, Heinbokel T, Desai BN, Cetina Biefer HR, Nian Y, Krenzien F, Matsunaga T, Uehara H, Maenosono R, Azuma H, Pratschke J, Falk CS, Lo T, Sheu E, Tavakkoli A, Abdi R, Perkins D, Alegre ML, Banks AS, Zhou H, Elkhal A, Tullius SG
(2021) Restored TDCA and valine levels imitate the effects of bariatric surgery. Elife 10
Bartesaghi S, et al.
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Bartesaghi S, Wallenius K, Hovdal D, Liljeblad M, Wallin S, Dekker N, Barlind L, Davies N, Seeliger F, Winzell MS, Patel S, Theisen M, Brito L, Bergenhem N, Andersson S, Peng XR
(2022) Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice. Mol Ther Nucleic Acids 28:500-513
Therapeutic Efficacy Evaluation, Metabolic Syndrome, NAFLD/NASH
Schwartzkopf CD, et al.
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Schwartzkopf CD, Hadcock JR, Liu G, Germano P, Roux J, Shea CM, Buys ES, Jones JE
(2022) Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model. Front Pharmacol 13:852080
Madhavan A, et al.
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Madhavan A, Kok BP, Rius B, Grandjean JMD, Alabi A, Albert V, Sukiasyan A, Powers ET, Galmozzi A, Saez E, Wiseman RL
(2022) Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat Commun 13(1):608
Metabolism, Diabetes (Type 2), Metabolic Syndrome, NAFLD/NASH
Fergusson G, et al.
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Fergusson G, Ethier M, Gu�vremont M, Chr�tien C, Attan� C, Joly E, Fioramonti X, Prentki M, Poitout V, Alquier T
(2014) Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice. Mol Metab 3(9):848-54
Metabolic Syndrome
Fisher-Wellman KH, et al.
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Fisher-Wellman KH, Ryan TE, Smith CD, Gilliam LA, Lin CT, Reese LR, Torres MJ, Neufer PD
(2016) A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice. Diabetes 65(11):3249-3261
Blumenfeld NR, et al.
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Blumenfeld NR, Kang HJ, Fenzl A, Song Z, Chung JJ, Singh R, Johnson R, Karakecili A, Feranil JB, Rossen NS, Zhang V, Jaggi S, McCarty B, Bessler S, Schwartz GJ, Grant R, Korner J, Kiefer FW, Gillette BM, Sia SK
(2018) A direct tissue-grafting approach to increasing endogenous brown fat. Sci Rep 8(1):7957
Stem Cells/Regenerative Medicine/Tissue Engineering, Metabolic Syndrome
Wang Z, et al.
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Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, M�ndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM
(2019) Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat. Med. 25(1):141-151
Mullican SE, et al.
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Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ, Rangwala SM
(2017) GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. Nat. Med.
Holst B, et al.
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Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, S�rensen G, Madsen AN, Xue Z, M�ller SK, Woldbye D, Qvortrup K, Huganir R, Stamou D, Kj�rulff O, Gether U
(2013) PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol. 11(4):e1001542
Camacho S, et al.
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Camacho S, Michlig S, de Senarclens-Bezen�on C, Meylan J, Meystre J, Pezzoli M, Markram H, le Coutre J
(2015) Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Sci Rep 5:7919
Penke M, et al.
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Penke M, Larsen PS, Schuster S, Dall M, Jensen BA, Gorski T, Meusel A, Richter S, Vienberg SG, Treebak JT, Kiess W, Garten A
(2015) Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet. Mol. Cell. Endocrinol. 412:65-72
Chen Y, et al.
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Chen Y, Song M, Riley JP, Hu CC, Peng X, Scheuner D, Bokvist K, Maiti P, Kahl SD, Montrose-Rafizadeh C, Hamdouchi C, Miller AR
(2016) A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes. Pharmacol Res Perspect 4(6):e00278
Diabetes (Type 2)
Shin Wen, et al.
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Shin Wen, Kavita S. Jadhav, David L. Williamson, Todd C. Rideout
(2013) Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice Journal of lipids
L.M. Vaanholt, et al.
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L.M. Vaanholt, R.E. Sinclair, S.E. Mitchell and J.R. Speakman
(2015) Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice Physiology & Behavior Volume 144, 15 May 2015, Pages 146�155
Fontaine DA, et al.
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Fontaine DA, Davis DB
(2016) Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33
Montgomery MK, et al.
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Montgomery MK, Hallahan NL, Brown SH, Liu M, Mitchell TW, Cooney GJ, Turner N
(2013) Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 56(5):1129-39
Pettersson US, et al.
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Pettersson US, Wald�n TB, Carlsson PO, Jansson L, Phillipson M
(2012) Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue. PLoS ONE 7(9):e46057
Vickers SP, et al.
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Vickers SP, Jackson HC, Cheetham SC
(2011) The utility of animal models to evaluate novel anti-obesity agents. Br. J. Pharmacol. 164(4):1248-62
Hariri N, et al.
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Hariri N, Thibault L
(2010) High-fat diet-induced obesity in animal models. Nutr Res Rev 23(2):270-99
Bradley RL, et al.
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Bradley RL, Jeon JY, Liu FF, Maratos-Flier E
(2008) Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am. J. Physiol. Endocrinol. Metab. 295(3):E586-94
Anderson SR, et al.
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Anderson SR, Gilge DA, Steiber AL, Previs SF
(2008) Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice. Metab. Clin. Exp. 57(3):347-54
Buettner R, et al.
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Buettner R, Sch�lmerich J, Bollheimer LC
(2007) High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15(4):798-808
Sumiyoshi M, et al.
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Sumiyoshi M, Sakanaka M, Kimura Y
(2006) Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice. J. Nutr. 136(3):582-7
Hambly C, et al.
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Hambly C, Adams A, Fustin JM, Rance KA, B�nger L, Speakman JR
(2005) Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet. Obes. Res. 13(3):556-66
Metabolic Syndrome
Hu CC, et al.
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Hu CC, Qing K, Chen Y
(2004) Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice. Obes. Res. 12(8):1264-70
Wei P, et al.
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Wei P, Lane PH, Lane JT, Padanilam BJ, Sansom SC
(2004) Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes. Diabetologia 47(9):1541-9
Diabetes (Type 2)
Xu H, et al.
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Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H
(2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112(12):1821-30
Harris RB, et al.
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Harris RB, Bowen HM, Mitchell TD
(2003) Leptin resistance in mice is determined by gender and duration of exposure to high-fat diet. Physiol. Behav. 78(4-5):543-55
Steppan CM, et al.
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Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA
(2001) The hormone resistin links obesity to diabetes. Nature 409(6818):307-12
M Van Heek, et al.
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M Van Heek, D S Compton, C F France, R P Tedesco, A B Fawzi, M P Graziano, E J Sybertz, C D Strader, and H R Davis, Jr
(1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 1997 Feb 1; 99(3): 385�390
Steven P Vickers, et al.
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Steven P Vickers, Helen C Jackson, and Sharon C Cheetham
(2011) The utility of animal models to evaluate novel anti-obesity agents Br J Pharmacol. 2011 Oct; 164(4): 1248�1262
Jina Hong, et al.
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Jina Hong, Renee E Stubbins, Rebekah R Smith, Alison E Harvey, and Nomel� P N��ez
(2009) Differential susceptibility to obesity between male, female and ovariectomized female mice Nutr J. 2009; 8: 11
Alesia Walker, et al.
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Alesia Walker, Barbara Pfitzner, Susanne Neschen, Melanie Kahle, Mourad Harir, Marianna Lucio, Franco Moritz, Dimitrios Tziotis, Michael Witting, Michael Rothballer, Marion Engel, Michael Schmid, David Endesfelder, Martin Klingenspor, Thomas Rattei, Wolfgang zu Castell, Martin Hrab� de Angelis, Anton Hartmann and Philippe Schmitt-Kopplin
(2014) Distinct signatures of host�microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet The ISME Journal (2014) 8, 2380�2396
Angela M. Gajda, et al.
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Angela M. Gajda, MS, Michael A. Pellizzon, Ph.D., Matthew R. Ricci, Ph.D. and Edward A. Ulman
(2007) Diet-Induced Metabolic Syndrome in Rodent Models Animal Lab News
Walker A, et al.
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Walker A, Pfitzner B, Neschen S, Kahle M, Harir M, Lucio M, Moritz F, Tziotis D, Witting M, Rothballer M, Engel M, Schmid M, Endesfelder D, Klingenspor M, Rattei T, Castell WZ, de Angelis MH, Hartmann A, Schmitt-Kopplin P
(2014) Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet. ISME J 8(12):2380-96
Infectious Disease, Microbiome
Rajpal DK, et al.
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Rajpal DK, Klein JL, Mayhew D, Boucheron J, Spivak AT, Kumar V, Ingraham K, Paulik M, Chen L, Van Horn S, Thomas E, Sathe G, Livi GP, Holmes DJ, Brown JR
(2015) Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models. PLoS ONE 10(12):e0145499
Diabetes (Type 1), Infectious Disease, Microbiome, Diabetes (Type 2)
Heiker JT, et al.
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Heiker JT, Kunath A, Kosacka J, Flehmig G, Knigge A, Kern M, Stumvoll M, Kovacs P, Bl�her M, Kl�ting N
(2014) Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains. Physiol. Genomics 46(11):377-84
Campbell SC, et al.
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Campbell SC, Wisniewski PJ, Noji M, McGuinness LR, H�ggblom MM, Lightfoot SA, Joseph LB, Kerkhof LJ
(2016) The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice. PLoS ONE 11(3):e0150502
Infectious Disease, Microbiome
Almind K, et al.
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Almind K, Kahn CR
(2004) Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53(12):3274-85
Cardiovascular, Metabolism

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