Tyrobp - Model 12665 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • 12665
  • The targeting vector has been generated using 129Sv DNA and transfected into 129Sv ES cell line.
  • Tyrobp exons 3 and 4 were removed by the neomycin resistance cassette, which is flanked by loxP sites.
  • The neomycin resistance gene has been deleted by transient transfection of Cre in targeted ES cells.
  • Chimeric mice were produced and germline transmission achieved.
  • Deletion of exons 3 and 4 should result in loss of function of the Tyrobp gene by deleting the transmembrane region and part of the cytoplasmic region.
  • The remaining recombination sites are located in intron regions of the genome.
  • See A.B.H. Bakker et al, Immunity 13, 345-353, 2000, for further details.

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Cryopreserved at Taconic



Official Gene Name:

TYRO protein tyrosine kinase binding protein

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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