The Prxo1-creERT2 mouse was developed in the laboratory of Taija Makinen at the London Research Institute. A cDNA encoding tamoxifen inducible Cre recombinase (CreERT2) followed by SV40 polyadenylation signal was introduced into the start codon of Prox1 in BAC clone RP23-190F21 using homologous recombination in bacteria. Founder lines were backcrossed to C57BL/6. Taconic received embryos from CRT in 2015.
Bazigou et al. 2011. Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. J Clin Invest. Aug 1; 121(8): 2984–2992.
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