An inducible cre deleter under the control of the prospero homeobox 1 (Prox1) promoter.
Cre recombination is inducible via administration of tamoxifen.
Allows specific and temporally controlled cre-loxP recombination (gene inactivation/activation) in Prox1-expressing tissues, including lymphatic endothelia.
Efficient recombination is observed during all developmental stages (embryonic, postnatal) and in adults.
Genetic Background: C57BL6
Origin: The Prxo1-creERT2 mouse was developed in the laboratory of Taija Makinen at the London Research Institute. A cDNA encoding tamoxifen inducible Cre recombinase (CreERT2) followed by SV40 polyadenylation signal was introduced into the start codon of Prox1 in BAC clone RP23-190F21 using homologous recombination in bacteria. Founder lines were backcrossed to C57BL/6. Taconic received embryos from CRT in 2015.