ICR scid

ICR scid Spontaneous Mutant Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
ICRSC-F IcrTac:ICR-Prkdcscidsp/sp
ICRSC-M IcrTac:ICR-Prkdcscidsp/sp
View:
Select One

Overview

Nomenclature: IcrTac:ICR-Prkdcscid

  • Equivalent to C.B-17 scids in severity of immunodeficiency, but this outbred background exhibits a significantly reduced incidence of spontaneous Ig production (leakiness)
  • Gains weight faster than the C.B-17 scid which makes the ICR-scid better suited for ascites production from heterohybridomas and as a host for tumor lines
  • Mice homozygous for the scid mutation lack both T and B cells due to a defect in V(D)J recombination. They easily accepts foreign tissue transplants, including human tumors, making them effective models for testing new cancer treatments. Scid mice are also useful for examining the relationship between immunity and disease.

Origin

The ICR scid spontaneous mutant model was developed by the Fox Chase Cancer Center by intercrossing ICR mice to C.B-17-SCID mice. The mice were then backcrossed two generations to a Icr:Ha(ICR) outbred background. Taconic received stock in 1992.

Genetics

Species:Mouse
Strain Type:Outbred or Mixed
Allele Type:Spontaneous Mutant
Coat Color:Albino
Coat Color Loci: Tyrc
Genetic Background:Other
Coat Color Loci: Tyrc

Guides & Publications

Applications & Therapeutic Areas

  • Immunology
  • Inflammation
  • Oncology & Immuno-Oncology

Transit, Housing & Welfare

Need more info? Click the live chat button or Contact Us

Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

Data

Average litter size: 7

For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. For orders sourced from US or Denmark a production minimum 3 gram span is accepted. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.

This chart is best viewed in landscape mode.
Please rotate your screen.

Loading...

n= 100 per sex at RF health standards from US colonies. Data collected 2013-15.
High and Low represent mean +/- 2 standard deviation.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Licensing

Terms of Sale and Use for ICR scid

These models are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services

Pricing - USD

Opportunist Free (OF) Health Standard

ICRSC Female

ICRSC-F Genotype sp/sp

Age in WeeksQuantity 1 - 99Quantity 100 - 999
3 to 5$67.00$62.00
6 to 8$81.00$74.00
9$94.00$85.00

Specialized Inventory

ICRSC-FLQuantity 1 - 199
Female With Litter$482.00

Specialized Inventory

ICRSC-UPQuantity 1 - 199
Untimed Pregnant Female$446.00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

ICRSC Male

ICRSC-M Genotype sp/sp

Age in WeeksQuantity 1 - 99Quantity 100 - 999
3 to 5$67.00$62.00
6 to 8$81.00$74.00
9$94.00$85.00

Pricing - EUR

Opportunist Free (OF) Health Standard

ICRSC Female

ICRSC-F Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 5€92,00
6 to 8€101,00
9€113,00

Specialized Inventory

ICRSC-UPQuantity 1 - 199
Untimed Pregnant Female€631,00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

ICRSC Male

ICRSC-M Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 5€92,00
6 to 8€101,00
9€113,00

Select my Health Standard

Need help choosing the right Taconic Biosciences health standard for your research?

Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.

Get custom pricing guide

2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

Schedule A Scientific Consultation

Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.

Want to Get in Touch?

Chat with us or reach out to our global team

phone

Webinar On-Demand

ON-DEMAND WEBINAR | Breed Vs. Buy: What's The Right Choice For Your Lab?

2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

Smart Select Program

Trial an Animal Model for Quality & Compatibility Assurance

As longtime facilitators of animal-based research, we understand the importance of aligning your project goals and procurement priorities to support advancements in your research. 

  • Evaluate a specific model strain, before making any financial investment
  • Request up to 20 animals from one of the strains listed below, to test for quality, consistency, and suitability for your experimental purpose
  • Enjoy free ground shipping, where applicable (see table for more details)*