ICR scid

• Equivalent to C.B-17 scid's in severity of immunodeficiency, but this outbred background exhibits a significantly reduced incidence of spontaneous Ig production (leakiness)
• Gains weight faster than the C.B-17 scid which makes the ICR-scid better suited for ascites production from heterohybridomas and as a host for tumor lines
• Outbred maintained in a specially equipped Isolated Barrier Unit™ (IBU™) where the flora is continuously monitored to assure the absence of specific opportunistic bacteria
• Mice homozygous for the Prkdc^scid mutation lack both T and B cells due to a defect in V(D)J recombination. Therefore, they easily accepts foreign tissue transplants, including human tumors, making them effective models for testing new cancer treatments and as hosts for human immune system tissues (i.e., SCID-hu). SCID mice are also useful for examining the relationship between immunity and disease.

For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. A minimum 3 gram span is required. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.

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