Constitutive Knockout

NOD Background

  • Model #
  • Genotype
  • Nomenclature
    NOD.Cg-Prkdcscid Il2rgtm1Sug/ JicTac
    NOD.Cg-Prkdcscid Il2rgtm1Sug/ JicTac
  • NOG mice engrafted with human CD34+ hematopoietic stem cells (HSCs) stably develop multiple cell lineages by 12-16 weeks post-injection.
  • Human lymphocytes are present in peripheral blood, bone marrow, thymus and spleen.
  • Long term studies are possible in huNOG mice, with literature reports of stable engraftment and hematopoiesis for one year or more. However, not all human immune cell types are present, and some cell types may not be completely functional.

Taconic maintains an inventory of female huNOG mice engrafted as juveniles and FACS tested around 16 weeks post-engraftment; all mice are ≥25% hCD45+ in peripheral blood. Custom options for huNOG generation and assessment of engraftment are available, such as HLA matching and age of engraftment.

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

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Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions

For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.

Does your research require the use of neonates? Please contact us for more information on neonate access options.

The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
  • Japanese Patent No. 3,753,321
  • US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
    EP Patent No. 1,338,198
  • Japanese Trademark Reg. No. 4,823,423
  • US Trademark Reg. No. 3,118,040
  • EU Trademark Reg. No. 3,736,758