Cre Deleter

Targeted Transgenic

Cre Deleter Targeted Transgenic Mouse Model

C57BL/6NTac Background

  • Model #
  • Genotype
  • Nomenclature
  • 12524-F
    ki/wt
    C57BL/6NTac-Gt(ROSA)26Sortm16(cre)Arte
  • 12524-M
    ki/wt
    C57BL/6NTac-Gt(ROSA)26Sortm16(cre)Arte
  • Ubiquitously active general Cre deleter.
  • This transgene is suspected to be homozygous lethal.
  • Maternal expression of Cre often leads to deletion of loxP flanked target genes in Cre-negative embryos.
  • This model replaces model 6467. Model 12524 is fully congenic on C57BL/6NTac.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

C57BL/6

Origin:

The Cre Deleter mouse was developed by Artemis Pharmaceuticals (now Taconic). The mutant was created by a targeted mutation knock in of Cre into the Gt(ROSA)26 locus. Cre is expressed under the control of the Gt(ROSA)26Sor gene. Additional sequence elements are adenovirus major late transcript splice acceptor sequence from the intron 1/exon2 boundary situated 5´ and FLP recombinase target (FRT) sequences (Saccharomyces cerevisiae) situated 3´ of Cre. Targeting occurred in C57BL/6N ES cells. The colony is maintained by breeding heterozygotes to wild type C57BL/6NTac mice.

Color:

Black

Species:

Mouse

Initial Publication:

Otto C, Fuchs I, Kauselmann G, Kern H, Zevnik B, Andreasen P, Schwarz G, Altmann H, Klewer M, Schoor M, Vonk R, Fritzemeier KH. (2009) GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod 80(1):34-41.


Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Access to this model requires execution of a Cre Deleter Research Breeding or Cross-breeding Agreement. Once the agreement is executed, you may order mice for use in breeding or cross-breeding. Please contact Taconic Customer Service for details.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Conditions of Use - Printable Version