Founded in 1952, Taconic Biosciences is an innovator and pioneer in the generation and production of rodent models.
Since then, we have grown into a global ecosystem of laboratories, breeding facilities, distributors, and partners. Our colony management team has supervised breeding projects comprising over 13,000 different strains of mice and rats, completed approximately 15,000 breeding projects, and services roughly 50,000 cages of animals per week. Each part of our network strives to provide customers with access to the highest quality of animal model products and services in the industry. The right animal model holds endless possibilities for drug discovery and advancements in human health.
The Colony Management Solutions team at Taconic has developed a comprehensive toolkit of services for animal model production & management that are designed to promote the success of any breeding project.
Taconic offers nearly 5,000 mouse models that are commercially-available for any breeding project, including inbred, outbred, congenic, and hybrid mice and rats; as well as spontaneous mutants, humanized models, and genetically engineered models (GEMs). If you require a custom GEM, Taconic's model design team is able to create a variety of mutations and supervise the breeding of this new model. Once your cohort has been established, we are able to offer pre-conditioning solutions, including custom diet administration, surgical services, custom microbiomes, and more. We also offer worldwide delivery of models using Taconic Transit Cages™ and can assist you in the model acquisition process.
Central to our model breeding and husbandry capabilities is our ability to house animals at multiple health standards and in multiple locations. We offer traditional barrier solutions as well as more specialized gnotobiotic housing facilities. Additionally, all models are monitored for their health and are overseen by board-certified veterinarians.
Leveraging our highly-skilled Embryology team, Taconic can conduct large scale embryo transfers through in vitro fertilization (IVF) for rapid colony scaling. When compared to natural mating, IVF enables the production of 20 - 500 mice within the same week of birth. These age-matched cohorts can also be rederived at any health standard, including Murine Pathogen Free™ (MPF™) and Germ Free for microbiome studies.
Taconic offers both sperm and embryo cryopreservation services to protect your colony from sudden loss due to disease, natural disasters, or reduced funding. This cryopreserved stock can also be used to refresh your colony and protect against genetic drift over the course of a long-term breeding project. Additionally, FRapid® expansion enables us to perform a rapid expansion from frozen sperm, producing over 100 mice with the same week of birth.
Taconic's Project Management and Scientific Program Management teams have years of experience in developing and maintaining successful breeding programs. Colony management customers have access to regular communication with their dedicated project manager and 24/7/365 web-based access to project data through our eTACONIC® platform. Each project includes a detailed project charter with specific milestones and deliverables customized for every project.
Genetic analysis is a key component of proper colony management. Taconic's genetic characterization services can accelerate the development of a new mutant model through speed congenics. Additionally, we offer multiple assays to analyze transgenes and gene expression.