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Characterization of Alzheimer's Disease Progression in Mouse Models Using 3D Intact
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  • Regulatory T Cells in Humanized Immune System Mice

    Regulatory T cells (Tregs) are a critical component of the immune system for regulating inflammatory responses. In the context of immune-mediated diseases, such as cancer or graft-versus-host disease (GvHD), Tregs can either drive or suppress disease pathogenesis. This two-sided role for Tregs and their impact... Read more

  • The Classic Diet-Induced Obese Mouse Model is Still Enabling Breakthroughs in Drug Discovery for Metabolic Diseases

    Obesity causes metabolic dysfunctions that lead to debilitating chronic diseases including type 2 diabetes, fatty liver disease, and cirrhosis. Diet-induced obese (DIO) rodents are popular models for studying obesity and pre-diabetes. In 1953, Fenton and Dowling manipulated nutrient composition across a range of refined rodent... Read more

  • Which Cre Strain Should You Use?

    Unique in its complexity, the central nervous system (CNS) has long represented a challenge for biomedical research, in part because the definition and characterization of constituent cell types remains incomplete. Indeed, one of the major goals behind the 2013 National Institutes of Health (NIH) launch... Read more

  • HLA Mice as a Model to Study T Cell Responses Restricted by Human MHC

    Introduction to HLA and MHC An HLA (Human Leukocyte Antigen) or human MHC (Major Histocompatibility Complex) is a group of surface protein complexes that presents antigens to downstream immune cells to activate the adaptive immune system against foreign pathogens or injured cells. These molecules are... Read more

  • Raising Heart Health Awareness: American Heart Month

    February marks American Heart Month — a campaign aimed at educating citizens about the importance of cardiovascular health. The National Heart, Lung, and Blood Institute (NHLBI) is encouraging visitors to their website to adopt heart-healthy behaviors through increasing exercise, as well as positive diet and... Read more

  • Autoimmunity in Humanized Immune System Mice: A Double-edged Sword

    A hyperactive immune system can be a positive or a negative in the disease setting depending on the desired outcome. Autoimmune diseases such as graft-versus-host disease, lupus, inflammatory bowel disease, arthritis, IPEX, and more are caused by the immune system attacking healthy host tissue. These... Read more

  • Webinar Q&A — Applications of Transgenic HLA Mice, From Vaccines to Immuno-oncology

    Dr. Courtney Ferrebee recently presented a webinar titled "Applications of Transgenic HLA Mice, From Vaccines to Immuno-oncology". The webinar presented an overview of Taconic Biosciences' catalog of class I and class II transgenic HLA models, including an introduction to the HLA system and the role... Read more

  • Studying Mast Cell-mediated Allergic Disease Using Humanized Immune System Mice

    Humanized immune system (HIS) mice have a variety of applications for studying diseases in which the immune system drives pathogenesis. This includes immuno-oncology, autoimmunity, and a less discussed but also crucial subset of immunologic disorders, allergy. Indeed, Taconic's CD34+ hematopoietic stem cell (HSC)-engrafted NOG-EXL (huNOG-EXL)... Read more

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