huNOG-EXL EA (Early Access): A Myeloid-Supportive HIS Model with a Longer Potential
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Humanized immune system (HIS) mice have a variety of applications for studying diseases in which the immune system drives pathogenesis. This includes immuno-oncology, autoimmunity, and a less discussed but also crucial subset of immunologic disorders, allergy. Indeed, Taconic's CD34+ hematopoietic stem cell (HSC)-engrafted NOG-EXL (huNOG-EXL)... Read more
Despite extensive global research activities and recent breakthroughs in therapeutics targeting the immune system in cancer patients, the clinical response to treatment can be transient or incomplete. This is due to the ability of cancer cells to adapt to environmental stress, including therapeutic insult, which... Read more
The interaction between chemokines and their receptors on immune cells is required for immune cells to move throughout the body and into peripheral tissues. Where these human chemokines come from and their levels in humanized immune system (HIS) mice has, until recently, been an unanswered... Read more
Numerous strains of mice will develop obesity, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH) when fed a "Western" diet enriched in saturated or trans fats, cholesterol, glucose, and fructose. This triggers weight gain, hepatic steatosis, and lipotoxic inflammation, leading to liver fibrosis and... Read more
Bile acids (BAs) are small detergent molecules that are primarily known for their ability to promote intestinal lipid absorption. While their primary function is associated with gut metabolism, they also are key players in other physiological signaling pathways related to microbiome maintenance, the regulation of... Read more
Humanized immune system mice are valuable tools for a wide variety of research including studies in immuno-oncology, autoimmune, and infectious disease. But understanding the utility of such models has been hampered somewhat by the wide variety of humanization protocols in use as well as donor-specific... Read more
Changing diets and lifestyles across much of the world contribute to a wide range of diseases and health conditions, including heart disease, hypertension, and type 2 diabetes. Another looming health crisis related to lifestyle is now on the horizon: a surge in the incidence of... Read more
The field of immuno-oncology continues to grow and its focus now includes various therapeutic approaches modulating one or more human immune cell types. T cells have been the most widely investigated and are the target of a spectrum of biologics; examples include manipulation of native... Read more
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