Immuno-Oncology Applications of Myeloid-Supportive Humanized Immune System Mice
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Numerous strains of mice will develop obesity, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH) when fed a "Western" diet enriched in saturated or trans fats, cholesterol, glucose, and fructose. This triggers weight gain, hepatic steatosis, and lipotoxic inflammation, leading to liver fibrosis and... Read more
Bile acids (BAs) are small detergent molecules that are primarily known for their ability to promote intestinal lipid absorption. While their primary function is associated with gut metabolism, they also are key players in other physiological signaling pathways related to microbiome maintenance, the regulation of... Read more
Humanized immune system mice are valuable tools for a wide variety of research including studies in immuno-oncology, autoimmune, and infectious disease. But understanding the utility of such models has been hampered somewhat by the wide variety of humanization protocols in use as well as donor-specific... Read more
Changing diets and lifestyles across much of the world contribute to a wide range of diseases and health conditions, including heart disease, hypertension, and type 2 diabetes. Another looming health crisis related to lifestyle is now on the horizon: a surge in the incidence of... Read more
The field of immuno-oncology continues to grow and its focus now includes various therapeutic approaches modulating one or more human immune cell types. T cells have been the most widely investigated and are the target of a spectrum of biologics; examples include manipulation of native... Read more
Schedule Consultation Dr. Janell Richardson recently presented a webinar on a case study that explored variance and its implications on study design in the huNOG-EXL, a humanized immune system (HIS) model. HIS models are the only in vivo model types to date that allow investigators... Read more
Immuno-oncology researchers are looking beyond T cells to other immune cells for the next cancer breakthrough. Myeloid cells (cells that originate from the common myeloid progenitor derived from hematopoietic stem cells in the bone marrow) are among those new targets. This class of immune cells... Read more
Mdr1a knockout mice are becoming a more frequently utilized colitis model in IBD research due to their translational relevance, microbiome-driven chronic phenotype of colitis, and presence of a functional immune system. However, the primary mechanisms by which colitis appears in the Mdr1a KO mouse are... Read more
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