PXR

Genetic Background:

Origin:

The PXR mouse was developed in the laboratory of Steven A. Kliewer at GlaxoSmithKline. The model was created by targeting the Nr1i2 gene in R1 embryonic stem cells derived from 129 mice and injecting the targeted cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed to C57BL/6J for two generations. Taconic received stock in 2000. The line was embryo transfer derived and backcrossed to C57BL/6NTac for a total of 10 generations (N10). The line was rederived in 2005. The colony is maintained through incrossing of homozygous mice.

Availability:

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Initial Publication:

Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98(6):3369-74.

Animal Diet:

• Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
• The Models will be used for research purposes only.
• The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless a breeding or cross-breeding agreement has been legally executed. Non-profit purchasers, of a breeding or cross-breeding agreement, may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless the breeding or cross-breeding agreement is purchased at the for-profit price. Please contact Taconic Customer Service for details.
• The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.