Carries a disruption of the nuclear receptor gene Nr1i2, which encodes the pregnane X receptor (PXR)
Useful for studies of xenobiotic metabolism
Useful for studies of cholestasis and hepatotoxicity
Genetic Background: C57BL/6 Background
Origin: The PXR mouse was developed in the laboratory of Steven A. Kliewer at GlaxoSmithKline. The model was created by targeting the Nr1i2 gene in R1 embryonic stem cells derived from 129 mice and injecting the targeted cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed to C57BL/6J for two generations. Taconic received stock in 2000. The line was embryo transfer derived and backcrossed to C57BL/6NTac for a total of 10 generations (N10). The line was rederived in 2005. The colony is maintained through incrossing of homozygous mice.
Occasionally, it becomes necessary to discontinue live production of Taconic Transgenic Models™ due to lack of interest. The PXR mouse developed in the laboratory of Steven A. Kliewer at GlaxoSmithKline is one such model. Live production of the model ended on May 15, 2013. If you have a need for a Pxr knockout mouse model, please contact us
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98(6):3369-74