In a recent webinar, Pharmatest — a contract research organization (CRO) with a global customer base specializing in preclinical efficacy in the areas of oncology and skeletal diseases — reported that super immunodeficient NOG mice exhibit no estrogen-related side effects, while more than 60% of nude mice exhibited adverse effects including bladder stones, rash, wounds, and skin irritations. Half of the experimental cohort of nude mice had to be sacrificed prior to planned completion of the experiment because of estrogen-related adverse affects.
On-Demand Webinar: Breast Cancer Xenograft ModelsIn this webinar, Pharmatest explored the impacts of external estrogen supplementation on various strains of mice used in preclinical breast cancer xenograft research.
- Why external estrogen supplements are necessary in breast cancer models
- What kinds of adverse, estrogen-related effects are observed in mouse models
- How to protect your research from strain-dependent variations in these effects