A hyperactive immune system can be a positive or a negative in the disease setting depending on the desired outcome. Autoimmune diseases such as graft-versus-host disease, lupus, inflammatory bowel disease, arthritis, IPEX, and more are caused by the immune system attacking healthy host tissue. These diseases can be modeled preclinically using humanized immune system (HIS) mice, with varying levels of success. Studying Autoimmune Diseases in NOG Mice... Read More