Alzheimer's Disease INSIGHTS

Alzheimer's Disease: Steps towards more translational research models

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Alzheimer's Disease International reports there are 50 million people worldwide living with Alzheimer's Disease (AD), but there remain few approved treatments and no cure. The amount spent to care for patients with AD is over $1 trillion USD, or 1% of global GDP, and experts believe that number will grow to 152 million people by 2050. So where are we in the search for an effective treatment...  Read More

New gene therapy for the treatment of Alzheimer's Disease

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It is estimated that 5.8 million Americans are currently living with Alzheimer's Disease (AD). AD is a progressive, lifelong condition for which there is currently no cure. Treatment consists of managing the symptoms associated with the disease and include medicines that aim to maintain mental function, manage behavioral symptoms, and slow down memory loss1,2. Many clinical trials are currently active in the study of AD-related drugs. One...  Read More

Alzheimer's Disease Awareness Month

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As Alzheimer's Disease Awareness Month concludes we review the state of Alzheimer's disease (AD) research, its biological mechanisms, and available in vivo research models of AD. Alzheimer's Disease Overview Since the original National Alzheimer's Disease Awareness Month in November 1983, the number of afflicted patients in the US has risen from two to five million; it is projected to increase to 14 million by 20501. AD is...  Read More

Tauopathy Alzheimer's Disease Models Yield Contrasting Results

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In a recent Alzheimer's Research and Therapy article, scientists described failing to elicit beneficial effects from a tau-directed antibody therapy while evaluating its efficacy in the Tg4510 mouse, an Alzheimer's disease (AD) model with a tamoxifen-controlled transgene expressing P301L mutant tau. The results contrast prior successes reported with the antibody therapy the researchers were testing. The therapeutic, a tau oligomer-specific monoclonal antibody (TOMA), was reported to rescue...  Read More

A Redox Link between APOE4 and Alzheimer's Disease Risk?

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A Redox Link between APOE4 and Alzheimer's Disease Risk? Individuals homozygous for APOE4, one of three common genetic variants encoding Apolipoprotein E (apoE), carry approximately twelve-times higher risk for an Alzheimer's disease (AD) diagnosis. A recent study suggests a potentially critical link between apoE4 and the antioxidant enzyme Thioredoxin-1 (Trx1) may underlie enhanced AD risk in APOE4 carriers. APOE Alleles Modify Alzheimer's Risk ApoE protein is predominantly...  Read More

Alzheimer's Requires Aggressive Funding — and Better Models

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More than 5.5 million Americans are living with Alzheimer's disease (AD), the sixth leading cause of death among adults in the US. Aggressive research funding and improved animal models of Alzheimer's disease are urgent priorities. Increasing Alzheimer's Research Funding On July 19, 2017, the House Appropriations Committee approved an additional $400 million for Alzheimer's disease research in the fiscal year 2018 budget. $400 million was also approved...  Read More

Rodent Alzheimer's Disease Model Supports New Therapies

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In late 2016 Biogen reported exciting results for aducanumab, their Phase 1 monoclonal antibody therapy for Alzheimer's disease (AD). Patients who received aducanumab showed significant and dose-dependent reduction of brain Amyloid-β (Aβ) and slowing of disease progression. Pre-clinical studies in the APPSWE/Tg2576 mouse model of AD provided the mechanistic clues, dosing insights, and efficacy data that informed the design of Biogen's successful aducanumab Phase I trial. Now,...  Read More

Investigating Tau Proteins in Alzheimer's Disease Mouse Models

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Despite tau proteins having essential roles in neurodegeneration and amyloid-mediated neurotoxicity, Alzheimer's disease (AD) therapeutic development has largely focused on amyloid-beta. Recent investigations, in humans and rodent Alzheimer's Disease models, suggest specific tau species might be major pathological contributors to AD progression and, as such, an even better target than amyloid-beta for effective AD therapies. Tau Proteins in Alzheimer's Disease Monomeric tau proteins are abundant in neurons,...  Read More

Targeting APOE4 for Alzheimer's Disease Therapies

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Past research efforts, focused on Alzheimer's disease (AD) pathology and the genetics of familial AD, led to the discovery of important AD-related proteins, including amyloid-beta (Aβ) and tau. However, efforts to develop AD therapies based on targeting Aβ and tau have largely failed. Years of disappointing trials have brought increasing demand for new AD targets and alternative treatment approaches. Using mice expressing apolipoprotein E4 (apoE4), a human...  Read More

Mother's Diet Influences Alzheimer's Disease Outcomes

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Increasingly obesity and its associated comorbidities (cardiovascular disease, type 2 diabetes mellitus, hypertension, etc.) are identified as risk factors for Alzheimer's disease (AD). Determining the link between diet and Alzheimer's disease has been challenging, in large part due to obesity's association with numerous systemic physiological changes. Recent studies suggest that poor maternal diet can influence epigenetic changes which predispose offspring to the development of metabolic syndromes. Since...  Read More