Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

What is Cytochrome P450?

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Cytochromes P450 (CYP) is a superfamily of proteins involved in metabolism and inactivation of foreign substances and toxins. Each protein in this family is highly specialized with unique, dedicated pathways inside the cell. CYPs are transmembrane proteins commonly found in the plasma membrane of the endoplasmic reticulum in liver cells and interact with ligands on both sides1. Using heme as a cofactor, these proteins aid in the...  Read More

Transportation Affects Gut Microbiome of Laboratory Mice

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Experimental controls are at the center of every quality experiment, and understanding the causes of microbiome variability is key to controlling for microbiome-related effects. Researchers that utilize murine models attempt to control for possible microbiome variability by ordering mice from the same vendor, using littermate controls, and employing co-housing strategies1. Given the ongoing research reproducibility crisis, it is vital to understand potential factors that contribute to microbiome...  Read More

Sexual dimorphism in fear learning memory due to epigenetic modification by Cdk5

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Epigenetics of FLM, Stress, and Neuro-Degenerative Disease The epigenetic post-translational modifications of histone (hPTMs) is a notable cellular response mechanism to environmental stimuli2. Emerging reports point to the sexual dimorphism of epigenetic hPTMs within the neurobehavioral context of fear, learning, and memory (FLM), in neuro-degenerative diseases, as well as stress- and trauma- related disorders3,4. Developmental and Functional Roles of Cdk5 One important protein in cognitive functions is...  Read More

How Animal Model Handling Affects Your Research

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Researchers who regularly work with mice and rats understand that incorrect handling practices creates unnecessary stress for the animal. If one is new to working with preclinical animal models, or is introducing a new strain to their work, a quick refresher on the benefits of correct handling procedures could be very useful. Improper Animal Handling Causes Stress Certain stressors that affect mice and rats cannot be avoided....  Read More

Studying T Cell Distribution in Syngeneic Tumor Models

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In a recent article in The Journal of Pharmacology and Experimental Therapeutics, Khot et al. examined the pharmacokinetics (PK) of exogenously administered T cells in a syngeneic tumor model. As immuno-oncology therapeutics expand into cell-based therapies, such as CAR-T cells, this type of research is needed to support their development. Khot et al. provide valuable insight into the PK of T cell-based therapeutics in this new paper....  Read More

Market Growth of Immuno-oncology Drugs Improve Cancer Treatments

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Figure 1: Companies actively pursuing immunotherapies. Source: Trends in the Global Immuno-oncology Landscape (2018) The approval of Ipilimumab (Yervoy®, BMS) in 2011 finally offered hope to metastatic melanoma patients — and set off a revolution in cancer treatment. Since 2011, regulatory agencies have approved eleven more immunotherapy drugs. Immunotherapy research continues to explode. There are close to thirty approved drugs that stimulate the immune system to kill...  Read More

EACR 2019 Conference Series Review

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The EACR Conference on Immuno-Oncology attracted academic and pharmaceutical researchers from all over the world to the Casa Milà in Barcelona, Spain. Attendees shared their recent findings in fundamental and translational research and discussed clinical studies in immuno-oncology and immunotherapy. EACR 2019 Immuno-Oncology Conference Series This Insight only highlights a small fraction of the discussions, seminars and presentations from this year's conference series. Speakers Richard Flavell and...  Read More

Overview of Genetic Modification Techniques

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The first genetically-modified mouse capable of transferring its modified genome to offspring was developed in the early 1980s. Since then, multiple genetic modification techniques have been developed to modify rodent genomes and are still commonly used today. Random and targeted transgenesis are commonly used today to study the effects of incorporating exogenous DNA for the purposes of expressing proteins not normally present in mice and rats, while...  Read More

Gut-Derived Iga+Ve Plasma Cells Suppresses Neuroinflammation in MS Mouse Model

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The glial cells play pivotal roles in the central nervous system (CNS) by supporting its development, maintaining homeostasis, producing myelin, and providing support and protection for neurons1. These cells are increasingly under scientific scrutiny in the pathogenesis of neurodegenerative disorders (ND). The activated microglia, a subset of glial cells, have been demonstrated to be the main determinant of neuroinflammation that contributes to neurodegeneration2. Increasing evidence supports the...  Read More