Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

2019 Microbiome Conferences

Looking for a microbiome conference or workshop? Here are some upcoming sessions we'll be following with interest. 2019 Microbiome Conferences: More Specific as Field Matures The Translational Microbiome Research Forum (TMRF) lists thirty-six 2019 conferences so far, and updates their Events page upon announcement of new meetings. While the majority (72%) of microbiome conferences in 2018 were of general interest, 2019 events are much more focused on...

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Seasonal Cycling in the Gut Microbiome of the Hadza Hunter-gatherers of Tanzania

Researchers from Stanford University published a paper in Science titled "Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania" which examines the relationship between diet, seasons, and the microbiome. The authors performed a longitudinal study on 350 stool samples collected throughout a year and a half and found that the microbial population in these samples changed in composition from wet to dry seasons as...

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Nature Biotechnology Publication: Translating microbiome futures

Figure 1: Over the past five years, the scientific output in the microbiome field and the number of microbiome-related published patents has been steadily rising. Sources: PubMed (search terms "human microbiome" and "human microbiota"); Fankhauser et al.; University of Chicago Technology Commercialization; CBInsights; CrunchBase; GlobalData; the companies. The publication of Translating microbiome futures is the culmination of more than a year's work by Gaspar Taroncher-Oldenberg, Consultant in...

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Sex Bias in Animal Model Research

The National Institutes of Health (NIH) announced new policies in 2014 aimed at requiring NIH-funded researchers to address sex balance in preclinical cell and rodent models. Although exclusion of women in clinical research was identified as problematic decades ago, the preclinical research world has not followed suit. The NIH identified this continued reliance of animal studies on a single sex, often male, as inappropriate: "consideration of sex...

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Rodent Sentinels — A Vital Link in Your Research

Rodent health monitoring programs (also referred to as rodent health surveillance or sentinel monitoring programs) are designed to detect subclinical infections of rodents that potentially have detrimental effects to the health of the animals or the integrity of your research. Robust sentinel animal protocols are both ethically and scientifically crucial. Sentinel Animal Protocols A health monitoring program is designed to detect infections that may be present within...

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Liver Awareness Month

October marks National Liver Awareness month. Estimates for the global burden of chronic liver disease range from 50 million to over 100 million affected individuals. According to the Centers for Disease Control and Prevention (CDC), from 2000 — 2015 there was a 31% increase in deaths from chronic liver disease. Numerous diseases ranging from liver cancer to non-alcoholic fatty liver disease (NAFLD) to hepatitis pose an increasing...

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CRISPR Patent Update: Broad vs. Berkeley

It was recently announced that the legal battle over the CRISPR/Cas9 patents is likely finished with the Broad Institute prevailing above UC Berkeley. This ongoing debate began in 2014 with multiple research groups and institutions claiming rights to the CRISPR/Cas9 technology. The researchers involved in this case are Dr. Jennifer Doudna (UC Berkeley) and Dr. Emmanuelle Charpentier (University of Vienna) who engineered the Cas9 endonuclease from a...

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Investigating Tauopathies with Transgenic Mice

In a recent manuscript by Musi and co-authors, a combinatorial approach was adopted to investigate the tauopathy-mediated mechanisms underlying human Alzheimer's Disease (AD) in post-mortem human brain tissue and transgenic mice1. Human neurodegenerative diseases comprise a heterogenous group of disorders, underpinned by complex interactions of cell-intrinsic and -extrinsic molecular mechanisms between multiple different neuronal and non-neuronal cell types. Understandably, the spatio-temporal isolation and investigation of specific pathogenic...

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2018 Nobel Prize in Physiology or Medicine Awarded to Two Immunologists

Source: Karolinska Institutet On Monday, October 1, 2018 the Nobel Committee announced the recipients of this year's Nobel Prize in Physiology or Medicine. The two Nobel laureates were James P. Allison — a professor and immunologist from MD Anderson Cancer Center — and Tasuku Honjo — an immunologist from Kyoto University. Both researchers split the prize evenly for their pioneering discoveries relating to "cancer therapy inhibition of...

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Transgenic Mice Play a Key Role in Global Polio Eradication Initiative (GPEI)

Humanity is on the verge of one of the greatest public health achievements in history — eradicating polio. The Global Polio Eradication Initiative (GPEI) has reduced polio cases by 99.9% since 1988, bringing the world closer than ever to ending polio for good. This means a world in which every child would be safe from the paralysis caused by the virus. What is Polio? Poliomyelitis (polio) is...

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