Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Humanized Mice in Infectious Disease Research

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Vaccines, HIV, and diseases affecting the human liver are challenging to model without humanization of immune response and creative tissue engineering. Learn more in our guide to using humanized mice in infectious disease research. Evaluating Vaccines in Humanized Mice The evaluation of specific antibody production requires an in vivo model; however, species differences limit the utility of experimental animals for this purpose. For example, the lack of...  Read More

New Rab29 Overexpression Mouse Model for Parkinson's Disease

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Parkinson's disease (PD) is the second most common neurodegenerative disease (after Alzheimer's disease) and the most common movement disorder. The worldwide incidence of PD has more than doubled since 1990 to an estimated 6.1 million PD patients globally in 20161. In the United States in 2017, the estimated total economic burden of PD was $51.9 billion (The Lewin Group, Inc., Final Report commissioned by and submitted to...  Read More

2020 Microbiome Conferences

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Looking for a microbiome conference or workshop? 2020 looks to be a banner year for microbiome conferences. Here are some upcoming sessions we'll be following with interest. 2020 Microbiome Conferences The Translational Microbiome Research Forum (TMRF) is still among the best options for finding microbiome-related events and workshops. They list over fifty 2020 conferences so far and are updating their event page as new meetings are announced....  Read More

Webinar Q&A — Controlling the Macroenvironment: A Novel Approach to Germ-free Derivations

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Dr. Cristina Weiner recently presented a webinar featuring a novel approach to germ-free derivations. She discussed the importance of understanding baseline performance and making incremental process improvements as well as how Taconic Biosciences developed and implemented a new facility design which supports improved germ-free derivation success. We present the full webinar Q&A here. Dr. Cristina Weiner: While recognizing that the germ-free integrity of the animal is most...  Read More

Joyeux Noël and Revolutions in Medicine

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To our Insights readers, Please accept our sincere gratitude for making Insights so widely read. It has been a delight providing these informative articles over the past few years. Please indulge us as we take a break from our standard format for this year-ending Insight. — The Taconic Biosciences' Insight Team What will you do as we near the end of the year? It's the time when...  Read More

Webinar Q&A — Validated Il10 Knockout Models for IBD Research

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Dr. Philip Dubé recently presented a webinar on validated Il10 knockout mouse models for IBD research. He gave an overview of research in this area and presented new data on these models from studies done by Boehringer Ingelheim and Incyte. Due to time constraints, many of the questions submitted during the webinar went unanswered. We present a full Q&A here. Characterization of Il10 Knockouts Dr. Philip Dubé:...  Read More

Webinar Q&A — Liver Biopsies in a Mouse Model of NASH

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Stephanie Oldham and Christian Rivera of AstraZeneca recently presented a webinar on the use of a survivable liver biopsy in NASH mouse models, which is a technique that can provide valuable information on disease stage in individual mice prior to study initiation. In particular, it can be used to exclude outliers and properly randomize the remaining mice into study groups. Due to time constraints, many of the...  Read More

CRISPR/Cas9 Intellectual Property Landscape for Rodent Model Generation

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CRISPR/Cas9 is an extremely useful tool for both academic and commercial researchers. It is also widely used in the generation of custom mice and rats from licensed animal model vendors. However, there are multiple patents covering this technology and understanding the differences between them is essential before utilizing CRISPR/Cas9 for model generation. This Insight will focus on two key CRISPR/Cas9 patents and how they have influenced model...  Read More

Genetic Background of Mice Influences Microbiome

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Source: Graphical Abstract. Khan et al., 20191 The microbiome continues to be an important topic in both human health research and in popular culture. The microbiome is cited as a factor in multiple diseases, neurological conditions, and immune responses to foreign pathogens. Specific compositions of gut commensal bacteria have been associated with an increased incidence of depression, varying responses to immunotherapies, and the progression of neurodegenerative disease...  Read More

Benefits of Humanized Mice for CAR-T Immunotherapy Studies

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CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. This type of immunotherapeutic utilizes T cells extracted from patient blood which are subsequently modified to target cancer cells. The modification enables these cells to express the chimeric antigen receptor (CAR) on the cellular surface, directing the CAR T cells to recognize and kill...  Read More